دورية أكاديمية
Photostabilization studies of antihypertensive 1,4-dihydropyridines using polymeric containers.
| العنوان: | Photostabilization studies of antihypertensive 1,4-dihydropyridines using polymeric containers. |
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| المؤلفون: | De Luca M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Ioele G; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Spatari C; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Ragno G; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy. Electronic address: gaetano.ragno@unical.it. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2016 May 30; Vol. 505 (1-2), pp. 376-82. Date of Electronic Publication: 2016 Apr 13. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Drug Packaging*, Antihypertensive Agents/*chemistry , Dihydropyridines/*chemistry , Polymers/*chemistry, Drug Stability ; Drug Storage ; Felodipine/chemistry ; Glass ; Light ; Pharmaceutical Solutions ; Photolysis ; Polyethylene Terephthalates/chemistry ; Time Factors |
| مستخلص: | 1,4-dihydropyridine antihypertensives (DHPs) are almost all dispensed in solid pharmaceutical formulations for their easy lability when exposed to light. This paper reports a study on the photoprotective effect of containers in different glassy or polymeric matrices with regard to four known DHPs when in solutions. The samples were subjected to forced degradation by means of a Xenon lamp, in accordance with the international rules on drug stability evaluation. The simultaneous determination of the drugs and their photoproducts was carried out by applying the multivariate curve resolution (MCR) methodology to the spectral data recorded along the irradiation test. This technique was able to determine the kinetic parameters and resolve the spectra of the photoproducts. The time required to reduce by 10% the concentration of the drug (t0.1) was adopted as a criterion to compare the protective ability of the containers. A significant photoprotection for all drugs tested was obtained by the use of polyethylene terephthalate (PET) containers. The best result was achieved for the felodipine solution in blue PET transparent bottle of 0.6mm thickness, reaching an almost complete stabilization up to six hours under stressing irradiation. In contrast, the glass containers, whether or not coloured, did not provide a satisfactory photoprotection of the drugs, showing in any case t0.1 values under 24min. These results can be a good opportunity to design new photoprotective pharmaceutical packaging for DHPs in liquid dosage form. (Copyright © 2016 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dihydropyridines; Felodipine; Felodipine (PubChem CID: 3333); Lercanidipine (PubChem CID: 65866); MCR analysis; Nifedipine (PubChem CID: 4485); Nimodipine (PubChem CID: 4497); PET containers; Photodegradation; Photostabilization |
| المشرفين على المادة: | 0 (Antihypertensive Agents) 0 (Dihydropyridines) 0 (Pharmaceutical Solutions) 0 (Polyethylene Terephthalates) 0 (Polymers) 7M8K3P6I89 (1,4-dihydropyridine) OL961R6O2C (Felodipine) |
| تواريخ الأحداث: | Date Created: 20160418 Date Completed: 20170410 Latest Revision: 20170410 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijpharm.2016.04.020 |
| PMID: | 27085645 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2016.04.020 |