دورية أكاديمية
أعرض في EDS

Clinicopathological Analysis and Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as Possible Markers for Severe Vivax Malaria.

التفاصيل البيبلوغرافية
العنوان: Clinicopathological Analysis and Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as Possible Markers for Severe Vivax Malaria.
المؤلفون: Ray S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Patel SK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Venkatesh A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Bhave A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Kumar V; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Singh V; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Chatterjee G; Dept of Biochemistry, Grant Govt Medical College and Sir JJ Group of Hospitals, Byculla, Mumbai 400008, India., Shah VG; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.; Wipro GE Healthcare, Mumbai, India., Sharma S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Renu D; Strand Life Sciences Pvt. Ltd., Hebbal, Bangalore 560024, India., Nafis N; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Gandhe P; Departments of Clinical Pharmacology, Seth GS Medical College &KEM Hospital, Parel, Mumbai 400012, India., Gogtay N; Departments of Clinical Pharmacology, Seth GS Medical College &KEM Hospital, Parel, Mumbai 400012, India., Thatte U; Departments of Clinical Pharmacology, Seth GS Medical College &KEM Hospital, Parel, Mumbai 400012, India., Sehgal K; PD Hinduja National Hospital &Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400016, India., Verma S; Medicine Department, Medical College Hospital Kolkata, 88, College Street, Kolkata 700073, India., Karak A; Medicine Department, Medical College Hospital Kolkata, 88, College Street, Kolkata 700073, India., Khanra D; Medicine Department, Medical College Hospital Kolkata, 88, College Street, Kolkata 700073, India., Talukdar A; Medicine Department, Medical College Hospital Kolkata, 88, College Street, Kolkata 700073, India., Kochar SK; Department of Medicine, Malaria Research Center, S.P. Medical College, Bikaner 334003, India., S B V; Department of Medicine, Malaria Research Center, S.P. Medical College, Bikaner 334003, India., Kochar DK; Department of Medicine, Malaria Research Center, S.P. Medical College, Bikaner 334003, India.; Department of Medicine, RUHS College of Medical Sciences, Jaipur, Rajasthan 302033, India., Rojh D; Department of Medicine, Malaria Research Center, S.P. Medical College, Bikaner 334003, India., Varma SG; Dept of Biochemistry, Grant Govt Medical College and Sir JJ Group of Hospitals, Byculla, Mumbai 400008, India., Gandhi MN; Centre for Research in Nanotechnology &Science, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Srikanth R; Proteomics Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007, India., Patankar S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Srivastava S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
المصدر: Scientific reports [Sci Rep] 2016 Apr 19; Vol. 6, pp. 24557. Date of Electronic Publication: 2016 Apr 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Proteomics*, Biomarkers/*blood , Cytoskeletal Proteins/*blood , Malaria, Vivax/*blood, Adult ; Apolipoproteins E/blood ; Connectin/blood ; Female ; Haptoglobins/metabolism ; Humans ; Malaria, Vivax/parasitology ; Oxidative Stress ; Plasmodium vivax/pathogenicity ; Serum Amyloid A Protein/metabolism ; Superoxide Dismutase/blood ; Vitronectin/blood
مستخلص: In Plasmodium vivax malaria, mechanisms that trigger transition from uncomplicated to fatal severe infections are obscure. In this multi-disciplinary study we have performed a comprehensive analysis of clinicopathological parameters and serum proteome profiles of vivax malaria patients with different severity levels of infection to investigate pathogenesis of severe malaria and identify surrogate markers of severity. Clinicopathological analysis and proteomics profiling has provided evidences for the modulation of diverse physiological pathways including oxidative stress, cytoskeletal regulation, lipid metabolism and complement cascades in severe malaria. Strikingly, unlike severe falciparum malaria the blood coagulation cascade was not found to be affected adversely in acute P. vivax infection. To the best of our knowledge, this is the first comprehensive proteomics study, which identified some possible cues for severe P. vivax infection. Our results suggest that Superoxide dismutase, Vitronectin, Titin, Apolipoprotein E, Serum amyloid A, and Haptoglobin are potential predictive markers for malaria severity.
References: Malar J. 2014;13:315. (PMID: 25124718)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Proteomics. 2015 Jan;15(2-3):394-407. (PMID: 25413884)
J Proteomics. 2015 Sep 8;127(Pt A):103-13. (PMID: 25982387)
Talanta. 2015 Nov 1;144:801-8. (PMID: 26452893)
Trans R Soc Trop Med Hyg. 2000 Apr;94 Suppl 1:S1-90. (PMID: 11103309)
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1805-10. (PMID: 11172032)
Br J Haematol. 2001 May;113(2):486-91. (PMID: 11380421)
Clin Biochem. 2001 Jun;34(4):341-4. (PMID: 11440737)
Am J Trop Med Hyg. 2001 Nov;65(5):614-22. (PMID: 11716124)
Hematology Am Soc Hematol Educ Program. 2002;:35-57. (PMID: 12446418)
Infect Immun. 2004 Oct;72(10):5630-7. (PMID: 15385460)
Br Med J. 1973 Jun 2;2(5865):515-8. (PMID: 4714466)
Southeast Asian J Trop Med Public Health. 1975 Sep;6(3):419-24. (PMID: 769173)
Bull World Health Organ. 1977;55(2-3):237-48. (PMID: 412602)
Blut. 1985 Nov;51(5):329-35. (PMID: 3933596)
J Med Assoc Thai. 1992 Jan;75 Suppl 1:190-4. (PMID: 1402463)
Arch Pathol Lab Med. 1993 Jul;117(7):719-23. (PMID: 8323437)
Adv Exp Med Biol. 1994;366:43-58. (PMID: 7771281)
Am J Hematol. 1997 Jan;54(1):23-9. (PMID: 8980257)
Methods Mol Biol. 1998;108:101-6. (PMID: 9921519)
Int J Parasitol. 2004 Dec;34(13-14):1441-50. (PMID: 15582521)
Biol Trace Elem Res. 2005 Aug;106(2):107-15. (PMID: 16116242)
Curr Top Microbiol Immunol. 2005;295:137-67. (PMID: 16265890)
FEBS Lett. 2005 Nov 7;579(27):6151-8. (PMID: 16246333)
FASEB J. 2006 Jun;20(8):1224-6. (PMID: 16603602)
Cell Host Microbe. 2009 Feb 19;5(2):191-9. (PMID: 19218089)
Trends Parasitol. 2009 May;25(5):220-7. (PMID: 19349210)
Trends Parasitol. 2009 Oct;25(10):452-7. (PMID: 19734097)
PLoS Negl Trop Dis. 2010;4(4):e650. (PMID: 20386593)
Lancet Infect Dis. 2011 Jan;11(1):57-64. (PMID: 21183147)
PLoS Negl Trop Dis. 2011 Jun;5(6):e1160. (PMID: 21738804)
PLoS One. 2011;6(10):e26495. (PMID: 22028888)
J Proteomics. 2011 Nov 18;74(12):2660-81. (PMID: 21596164)
J Proteomics. 2012 Jun 6;75(10):3063-80. (PMID: 22086083)
PLoS One. 2012;7(8):e41751. (PMID: 22912677)
PLoS Negl Trop Dis. 2012;6(9):e1814. (PMID: 22970336)
Malar J. 2012;11:297. (PMID: 22929459)
Int J Mol Sci. 2012;13(12):16346-72. (PMID: 23208374)
Clin Microbiol Rev. 2013 Jan;26(1):36-57. (PMID: 23297258)
PLoS One. 2013;8(4):e61170. (PMID: 23585879)
J Infect Dis. 2013 Nov 1;208(9):1494-503. (PMID: 23888081)
Med Hypotheses. 2013 Nov;81(5):777-83. (PMID: 23978689)
Proteomics Clin Appl. 2014 Feb;8(1-2):53-72. (PMID: 24293340)
Mem Inst Oswaldo Cruz. 2014 Apr;109(2):154-62. (PMID: 24676654)
PLoS Pathog. 2014 Apr;10(4):e1004038. (PMID: 24743550)
Trends Mol Med. 2014 May;20(5):293-301. (PMID: 24508275)
Br J Haematol. 2011 Sep;154(6):680-9. (PMID: 21718279)
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W645-50. (PMID: 16912992)
J Vector Borne Dis. 2006 Sep;43(3):95-103. (PMID: 17024857)
Clin Biochem. 2007 Mar;40(5-6):377-82. (PMID: 17307156)
Microcirculation. 2008 Feb;15(2):81-107. (PMID: 18260002)
Parasitol Res. 2008 Mar;102(4):571-6. (PMID: 18066597)
Malar J. 2008;7:41. (PMID: 18312656)
Trends Parasitol. 2008 Jun;24(6):258-63. (PMID: 18467176)
PLoS Med. 2008 Jun 17;5(6):e128. (PMID: 18563962)
PLoS Med. 2008 Jun 17;5(6):e136. (PMID: 18563965)
Mem Inst Oswaldo Cruz. 2008 Sep;103(6):517-21. (PMID: 18949318)
Sci Rep. 2014;4:7140. (PMID: 25413266)
المشرفين على المادة: 0 (Apolipoproteins E)
0 (Biomarkers)
0 (Connectin)
0 (Cytoskeletal Proteins)
0 (Haptoglobins)
0 (Serum Amyloid A Protein)
0 (Vitronectin)
EC 1.15.1.1 (Superoxide Dismutase)
تواريخ الأحداث: Date Created: 20160420 Date Completed: 20170309 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4835765
DOI: 10.1038/srep24557
PMID: 27090372
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep24557