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أعرض في EDS

Impaired Ca(2+) Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia.

التفاصيل البيبلوغرافية
العنوان: Impaired Ca(2+) Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia.
المؤلفون: Nonato AO; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjao, 6930, 78600-000, Barra do Garças, Mato Grosso, Brazil., Olivon VC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Dela Justina V; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjao, 6930, 78600-000, Barra do Garças, Mato Grosso, Brazil., Zanotto CZ; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Webb RC; Department of Physiology, Augusta University, Augusta, GA, USA., Tostes RC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Lima VV; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjao, 6930, 78600-000, Barra do Garças, Mato Grosso, Brazil., Giachini FR; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjao, 6930, 78600-000, Barra do Garças, Mato Grosso, Brazil. fernandagiachini@hotmail.com.
المصدر: Inflammation [Inflammation] 2016 Jun; Vol. 39 (3), pp. 1188-97.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
مواضيع طبية MeSH: Homeostasis*, Calcium/*metabolism , Endotoxemia/*physiopathology , Mesenteric Arteries/*physiopathology , ORAI1 Protein/*metabolism, Animals ; Cells, Cultured ; Endotoxemia/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Muscle, Smooth, Vascular/pathology ; ORAI1 Protein/analysis ; Rats ; Rats, Wistar ; Stromal Interaction Molecule 1/analysis ; Stromal Interaction Molecule 1/metabolism ; Vasoconstrictor Agents/pharmacology
مستخلص: We hypothesized that SIRS/endotoxemia-associated hyporesponsiveness to vasoconstrictors is mediated by smaller increases in intracellular Ca(2+) levels due to reduced signaling via the STIM/Orai. Male Wistar rats were injected either with saline or bacterial LPS (i.p.; 10 mg/kg), and experiments were performed 24 h later. LPS-injected rats exhibited decreased systolic blood pressure, increased heart rate, neutrophils' migration into the peritoneal cavity, and elevated alanine aminotransferase levels. Additionally, second-order mesenteric arteries from endotoxemic rats displayed hyporeactivity to contractile agents such as phenylephrine and potassium chloride; decreased contractile responses to Ca(2+); reduced contraction during Ca(2+) loading; and smaller intracellular Ca(2+) stores. Decreased Orai1, but not STIM1, expression was found in resistance mesenteric arteries from LPS-treated rats. Additionally, cultured vascular smooth muscle cell (VSMC) treated with LPS resulted in increased TLR-4 expression, but Myd-88 and STIM-1 expression were not changed. Our data suggest that in endotoxemia, Ca(2+) homeostasis is disrupted in VSMC, with decreased Ca(2+) influx, smaller concentrations of Ca(2+) in the sarcoplasmic reticulum, and decreased activation of Orai1. Abnormal Ca(2+) handling contributes to LPS-associated vascular hyporeactivity.
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فهرسة مساهمة: Keywords: calcium homeostasis; hypotension; vascular reactivity; vascular smooth muscle cell
المشرفين على المادة: 0 (Lipopolysaccharides)
0 (ORAI1 Protein)
0 (Orai1 protein, rat)
0 (Stim1 protein, rat)
0 (Stromal Interaction Molecule 1)
0 (Vasoconstrictor Agents)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20160422 Date Completed: 20170309 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s10753-016-0354-y
PMID: 27099074
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2576
DOI:10.1007/s10753-016-0354-y