دورية أكاديمية
Disease Course and Colectomy Rate of Ulcerative Colitis: A Follow-up Cohort Study of a Referral Center in Tuscany.
| العنوان: | Disease Course and Colectomy Rate of Ulcerative Colitis: A Follow-up Cohort Study of a Referral Center in Tuscany. |
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| المؤلفون: | Manetti N; Department of Emergency, Division of Gastroenterology, AOU Careggi Hospital, Florence, Italy; and†IBD Regional Referral Center, AOU Careggi Hospital, Florence, Italy., Bagnoli S, Rogai F, Bonanomi AG, Vannozzi G, Giannotta M, Annese V |
| المصدر: | Inflammatory bowel diseases [Inflamm Bowel Dis] 2016 Aug; Vol. 22 (8), pp. 1945-53. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : [Oxford] : Oxford University Press Original Publication: New York, NY : Raven Press, c1995- |
| مواضيع طبية MeSH: | Colectomy/*statistics & numerical data , Colitis, Ulcerative/*drug therapy , Colitis, Ulcerative/*surgery , Colorectal Neoplasms/*etiology, Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Child ; Cholangitis, Sclerosing/etiology ; Colitis, Ulcerative/complications ; Eye Diseases/etiology ; Female ; Follow-Up Studies ; Humans ; Immunologic Factors/therapeutic use ; Italy ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Skin Diseases/etiology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Young Adult |
| مستخلص: | Background: The disease course and colectomy rate of ulcerative colitis (UC) vary largely in population-based and referral center cohorts. We retrospectively evaluated our cohort to determine the disease course and risk factors for colectomy. Methods: A cohort of 1723 ulcerative colitis patients (986 males; mean age, 34.8 ± 15.4 yrs) were identified and followed since 1960s for a mean of 11 ± 9 years (range, 1-49 yrs). Results: The disease extension was classified as E1, E2, and E3 on diagnosis at 19.7%, 54.2%, and 26.1% of patients, respectively. At the final follow-up, the disease extension increased in 20% of the cases. Extraintestinal manifestations (EIMs) were reported by 11% of the patients, whereas systemic corticosteroids (CS), IM or anti-TNFα agents were used by 68.6%, 20.4%, and 6.4% of patients, respectively. The crude colectomy rate was 7% (120 pts), with a 1.2% rate (n = 21) at 1 year from diagnosis (95% CI, 0.7-1.7) and a Kaplan-Meyer estimation of up to 18.2% after 30 years of follow-up. The 1-year colectomy rate showed no significant difference through the decades, whereas the 5-year and 10-year absolute value of colectomy was halved in the last 2 decades compared with the period from 1960 to 1990 (P = 0.01), with a general trend of a reduced colectomy rate at survival curves (P = 0.056). Conclusions: The colectomy rate was low in our cohort and further reduced in the last 2 decades. However, despite the availability of anti-TNFα agents, no further significant reduction of colectomies was observed in the last decade. |
| المشرفين على المادة: | 0 (Adrenal Cortex Hormones) 0 (Immunologic Factors) 0 (Tumor Necrosis Factor-alpha) |
| تواريخ الأحداث: | Date Created: 20160423 Date Completed: 20180202 Latest Revision: 20180913 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/MIB.0000000000000787 |
| PMID: | 27104823 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-4844 |
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| DOI: | 10.1097/MIB.0000000000000787 |