دورية أكاديمية
Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription.
| العنوان: | Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription. |
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| المؤلفون: | Gerasimova NS; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia., Pestov NA; b Department of Pharmacology , Rutgers-Robert Wood Johnson Medical School , Piscataway , NJ , USA., Kulaeva OI; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia.; c Cancer Epigenetics Program, Fox Chase Cancer Center , Philadelphia , PA , USA., Clark DJ; d Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA., Studitsky VM; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia.; b Department of Pharmacology , Rutgers-Robert Wood Johnson Medical School , Piscataway , NJ , USA.; c Cancer Epigenetics Program, Fox Chase Cancer Center , Philadelphia , PA , USA. |
| المصدر: | Transcription [Transcription] 2016 May 26; Vol. 7 (3), pp. 91-5. Date of Electronic Publication: 2016 Apr 26. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101530967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2154-1272 (Electronic) Linking ISSN: 21541272 NLM ISO Abbreviation: Transcription Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
| مواضيع طبية MeSH: | DNA Repair* , Transcription, Genetic*, DNA/*chemistry, Animals ; Chromatin/chemistry ; DNA/genetics ; DNA Damage ; Humans ; Nucleic Acid Conformation ; RNA Polymerase II/metabolism |
| مستخلص: | RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure. |
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| معلومات مُعتمدة: | P30 CA006927 United States CA NCI NIH HHS; R01 GM058650 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: DNA repair; DNA supercoiling; RNA polymerase II; chromatin; elongation; intermediates; intranucleosomal DNA loops; mechanism; nucleosome; single strand DNA breaks; structure; transcription |
| المشرفين على المادة: | 0 (Chromatin) 9007-49-2 (DNA) EC 2.7.7.- (RNA Polymerase II) |
| تواريخ الأحداث: | Date Created: 20160427 Date Completed: 20171025 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4984681 |
| DOI: | 10.1080/21541264.2016.1182240 |
| PMID: | 27115204 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2154-1272 |
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| DOI: | 10.1080/21541264.2016.1182240 |