دورية أكاديمية
Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription.
العنوان: | Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription. |
---|---|
المؤلفون: | Gerasimova NS; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia., Pestov NA; b Department of Pharmacology , Rutgers-Robert Wood Johnson Medical School , Piscataway , NJ , USA., Kulaeva OI; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia.; c Cancer Epigenetics Program, Fox Chase Cancer Center , Philadelphia , PA , USA., Clark DJ; d Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA., Studitsky VM; a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia.; b Department of Pharmacology , Rutgers-Robert Wood Johnson Medical School , Piscataway , NJ , USA.; c Cancer Epigenetics Program, Fox Chase Cancer Center , Philadelphia , PA , USA. |
المصدر: | Transcription [Transcription] 2016 May 26; Vol. 7 (3), pp. 91-5. Date of Electronic Publication: 2016 Apr 26. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101530967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2154-1272 (Electronic) Linking ISSN: 21541272 NLM ISO Abbreviation: Transcription Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
مواضيع طبية MeSH: | DNA Repair* , Transcription, Genetic*, DNA/*chemistry, Animals ; Chromatin/chemistry ; DNA/genetics ; DNA Damage ; Humans ; Nucleic Acid Conformation ; RNA Polymerase II/metabolism |
مستخلص: | RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure. |
References: | Mol Cell. 2015 Dec 3;60(5):742-54. (PMID: 26626479) Nature. 1997 Sep 18;389(6648):251-60. (PMID: 9305837) Cell. 1988 Dec 2;55(5):849-56. (PMID: 2847873) Mol Cell. 2006 Nov 17;24(4):559-68. (PMID: 17188033) Nucleic Acids Res. 2014 Nov 10;42(20):12512-22. (PMID: 25348398) Biophys J. 2009 Dec 16;97(12):3150-7. (PMID: 20006952) EMBO J. 1997 Aug 15;16(16):5046-56. (PMID: 9305646) Nature. 2012 Apr 11;485(7398):376-80. (PMID: 22495300) Nat Struct Mol Biol. 2009 Dec;16(12):1272-8. (PMID: 19935686) Proc Natl Acad Sci U S A. 1987 Oct;84(20):7024-7. (PMID: 2823250) DNA Repair (Amst). 2010 Sep 4;9(9):985-93. (PMID: 20674513) Science. 1997 Dec 12;278(5345):1960-3. (PMID: 9395401) EMBO J. 1991 Feb;10(2):387-95. (PMID: 1991452) Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5787-95. (PMID: 26460019) Nucleus. 2014 May-Jun;5(3):211-8. (PMID: 24819949) Sci Adv. 2015 Jul 03;1(6):e1500021. (PMID: 26601207) Mol Cell Biol. 1999 Jan;19(1):934-40. (PMID: 9858617) Mol Cell. 2007 Jul 6;27(1):135-47. (PMID: 17612496) Cell. 1980 Oct;21(3):773-83. (PMID: 6254668) Nat Rev Genet. 2008 Aug;9(8):619-31. (PMID: 18626472) Nucleus. 2014 May-Jun;5(3):195-202. (PMID: 24755522) Cell. 1994 Jan 28;76(2):371-82. (PMID: 8293470) Radiat Res. 1997 Jul;148(1):22-8. (PMID: 9216614) |
معلومات مُعتمدة: | P30 CA006927 United States CA NCI NIH HHS; R01 GM058650 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: DNA repair; DNA supercoiling; RNA polymerase II; chromatin; elongation; intermediates; intranucleosomal DNA loops; mechanism; nucleosome; single strand DNA breaks; structure; transcription |
المشرفين على المادة: | 0 (Chromatin) 9007-49-2 (DNA) EC 2.7.7.- (RNA Polymerase II) |
تواريخ الأحداث: | Date Created: 20160427 Date Completed: 20171025 Latest Revision: 20181113 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4984681 |
DOI: | 10.1080/21541264.2016.1182240 |
PMID: | 27115204 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2154-1272 |
---|---|
DOI: | 10.1080/21541264.2016.1182240 |