دورية أكاديمية
أعرض في EDS

Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis from HIV-infected Patients Undergoing Highly Active Antiretroviral Therapy.

التفاصيل البيبلوغرافية
العنوان: Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis from HIV-infected Patients Undergoing Highly Active Antiretroviral Therapy.
المؤلفون: Gama TG; Post-graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil., Pires FR; Post-graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil., Armada L; Post-graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil., Gonçalves LS; Post-graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: luciogoncalves@yahoo.com.br.
المصدر: Journal of endodontics [J Endod] 2016 Jun; Vol. 42 (6), pp. 921-7. Date of Electronic Publication: 2016 Apr 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7511484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3554 (Electronic) Linking ISSN: 00992399 NLM ISO Abbreviation: J Endod
أسماء مطبوعة: Publication: New York : Elsevier
Original Publication: Chicago, American Dental Assocation, <1975-1982>.
مواضيع طبية MeSH: Biomarkers*, Antiretroviral Therapy, Highly Active/*methods , HIV Infections/*complications , Periapical Periodontitis/*complications , Periapical Periodontitis/*immunology , Periapical Periodontitis/*pathology, Adult ; Aged ; Antigens, CD/analysis ; Antigens, CD20/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Brazil ; CD3 Complex/analysis ; CD4 Antigens/analysis ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Immunohistochemistry ; Interferon-gamma/immunology ; Interleukin-18/immunology ; Interleukin-6/immunology ; Male ; Middle Aged ; Periapical Granuloma/immunology ; Periapical Granuloma/pathology ; Periapical Periodontitis/diagnostic imaging ; Radicular Cyst/complications ; Radicular Cyst/immunology ; Radicular Cyst/pathology ; Smoking ; T-Lymphocytes/immunology ; Tumor Necrosis Factor-alpha/immunology
مستخلص: Introduction: This study tested the hypothesis that the inflammatory cell profile (CD3-, CD4-, CD8-, CD20-, and CD68-positive cells) and the expression of immunologic markers (tumor necrosis factor α, interferon-γ, interleukin-6, and interleukin-18) in chronic apical periodontitis are the same between non-HIV-infected patients and HIV-infected patients undergoing highly active antiretroviral therapy (HAART).
Methods: Thirty-four surgically excised chronic apical periodontitis lesions were sampled from 34 patients (17 HIV-infected and 17 non-HIV-infected). The lesions were extracted from teeth with no previous endodontic treatment. All HIV-infected patients were undergoing HAART. The specimens were submitted to histopathologic and immunohistochemical analyses by using an optical microscope. Immunoexpression was graded into 2 levels, focal to weak and moderate to strong. The χ(2), Fisher exact, and Mann-Whitney tests were used to analyze all significant differences between groups.
Results: Periapical cysts represented 70.6% and 52.9% of the lesions in the HIV-infected and non-HIV-infected groups, respectively; however, no statistically significant difference was observed (P = .481). There were no statistically significant differences between groups for the inflammatory cell profile and for any of the immunologic markers (P > .05).
Conclusions: There are no statistically significant differences of the cellular profile and expression of immunologic markers in chronic apical periodontitis between non-HIV-infected patients and HIV-infected patients undergoing HAART.
(Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Chronic apical periodontitis; HIV infection; immunohistochemistry; periapical cyst; periapical granuloma
المشرفين على المادة: 0 (Antigens, CD)
0 (Antigens, CD20)
0 (Antigens, Differentiation, Myelomonocytic)
0 (Biomarkers)
0 (CD3 Complex)
0 (CD4 Antigens)
0 (CD68 antigen, human)
0 (IL6 protein, human)
0 (Interleukin-18)
0 (Interleukin-6)
0 (Tumor Necrosis Factor-alpha)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20160428 Date Completed: 20170922 Latest Revision: 20171116
رمز التحديث: 20240628
DOI: 10.1016/j.joen.2016.03.008
PMID: 27118467
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-3554
DOI:10.1016/j.joen.2016.03.008