دورية أكاديمية
An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy.
| العنوان: | An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. |
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| المؤلفون: | Baldoni AO; Federal University of São João Del-Rei (UFSJ), Divinópolis, MG, Brazil., Freitas-Lima P; Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil., de Santi Ferreira FI; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), Ribeirão Preto, SP, Brazil., Martinez EZ; Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil., Queiroz RH; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), Ribeirão Preto, SP, Brazil., Sakamoto AC; Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil., Alexandre V; Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil., Perucca E; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.; C. Mondino National Neurological Institute, Pavia, Italy., Pereira LR; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), Ribeirão Preto, SP, Brazil. |
| المصدر: | Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2016 Jul; Vol. 43 (7), pp. 685-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print Cited Medium: Internet ISSN: 1440-1681 (Electronic) Linking ISSN: 03051870 NLM ISO Abbreviation: Clin Exp Pharmacol Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Anticonvulsants/*pharmacokinetics , Anticonvulsants/*therapeutic use , Epilepsy/*drug therapy , Epilepsy/*metabolism , Triazines/*pharmacokinetics , Triazines/*therapeutic use, Adult ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Drug Interactions/physiology ; Drug Therapy, Combination/methods ; Female ; Humans ; Kinetics ; Lamotrigine ; Male ; Valproic Acid/therapeutic use ; Young Adult |
| مستخلص: | Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication on LTG apparent oral clearance (CL/F). A therapeutic drug-monitoring database was used to identify steady-state plasma LTG concentrations in 210 patients. LTG CL/F values were calculated for each patient according to the equation CL/F (L/h per kg) = LTG daily dose (mg/kg)/Css (steady state concentration) (mg/L) × 24 h. A linear-regression model was used to assess the influence of gender, dose, age, and body weight in LTG CL/F. The influence of comedication on LTG CL/F was investigated by applying the Bonferroni post-test. The lowest LTG CL/F was found in patients comedicated with valproate (VPA) (mean, 0.0183 L/h per kg), followed by patients receiving VPA + enzyme inducers (0.0271 L/h per kg), patients on LTG monotherapy (0.0298 L/h per kg) and patients comedicated with enzyme inducers (0.056 L/h per kg) LTG CL/F correlated significantly with LTG dose (P < 0.01), but showed no significant relationship with gender, weight, and age. LTG CL/F is influenced by the type of antiepileptic comedication. The correlation with dose may be a spurious finding related to the fact that physicians, in adjusting dosage according to clinical response, are more likely to use larger doses in patients with high clearance values. (© 2016 John Wiley & Sons Australia, Ltd.) |
| المشرفين على المادة: | 0 (Anticonvulsants) 0 (Triazines) 614OI1Z5WI (Valproic Acid) U3H27498KS (Lamotrigine) |
| تواريخ الأحداث: | Date Created: 20160428 Date Completed: 20170905 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/1440-1681.12584 |
| PMID: | 27120710 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1681 |
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| DOI: | 10.1111/1440-1681.12584 |