دورية أكاديمية

Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications.

التفاصيل البيبلوغرافية
العنوان: Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications.
المؤلفون: Guo Z; The Liver Diseases Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China; Department of Gastroenterology, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. China., Peng H; The Liver Diseases Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China; Hebei Medical University Graduate School, Shijiazhuang, Hebei 050017, P.R. China., Kang J; The Liver Diseases Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China., Sun D; The Liver Diseases Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China.
المصدر: Biomedical reports [Biomed Rep] 2016 May; Vol. 4 (5), pp. 528-534. Date of Electronic Publication: 2016 Mar 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: [Spandidos Publications] Country of Publication: England NLM ID: 101613227 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2049-9434 (Print) Linking ISSN: 20499434 NLM ISO Abbreviation: Biomed Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : [Spandidos Publications], [2013]-
مستخلص: Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse peptides with 5-30 amino acids. CPPs are divided into cationic, amphipathic and hydrophobic CPPs. They are able to carry small molecules, plasmid DNA, small interfering RNA, proteins, viruses, imaging agents and other various nanoparticles across the cellular membrane, resulting in internalization of the intact cargos. However, the mechanisms of CPP internalization remain to be elucidated. Recently, CPPs have received considerable attention due to their high transduction efficiency and low cytotoxicity. These peptides have a significant potential for diagnostic and therapeutic applications, such as delivery of fluorescent or radioactive compounds for imaging, delivery of peptides and proteins for therapeutic application, and delivery of molecules into induced pluripotent stem cells for directing differentiation. The present study reviews the classifications and transduction mechanisms of CPPs, as well as their potential applications.
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فهرسة مساهمة: Keywords: cell-penetrating peptides; internalization; peptide therapeutic; protein transduction domain
تواريخ الأحداث: Date Created: 20160429 Latest Revision: 20240526
رمز التحديث: 20240526
مُعرف محوري في PubMed: PMC4840506
DOI: 10.3892/br.2016.639
PMID: 27123243
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9434
DOI:10.3892/br.2016.639