دورية أكاديمية
Group 3 innate lymphoid cells in tissue damage and graft-versus-host disease pathogenesis.
| العنوان: | Group 3 innate lymphoid cells in tissue damage and graft-versus-host disease pathogenesis. |
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| المؤلفون: | Karrich JJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Cupedo T |
| المصدر: | Current opinion in hematology [Curr Opin Hematol] 2016 Jul; Vol. 23 (4), pp. 410-5. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams And Wilkins Country of Publication: United States NLM ID: 9430802 Publication Model: Print Cited Medium: Internet ISSN: 1531-7048 (Electronic) Linking ISSN: 10656251 NLM ISO Abbreviation: Curr Opin Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : Lippincott Williams And Wilkins Original Publication: Philadelphia, PA : Current Science, c1993- |
| مواضيع طبية MeSH: | Immunity, Innate*, Graft vs Host Disease/*etiology , Graft vs Host Disease/*metabolism , Lymphocyte Subsets/*immunology , Lymphocyte Subsets/*metabolism, Animals ; Cytokines/metabolism ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia/complications ; Leukemia/therapy ; Transplantation, Homologous |
| مستخلص: | Purpose of Review: Innate lymphoid cells (ILC) have emerged as modulators of conditioning-induced tissue damage and development of graft-versus-host disease (GVHD) in the context of allogeneic hematopoietic stem cell transplantation (HSCT). This review highlights experimental and clinical evidence for a role of ILC in GVHD pathogenesis. Recent Findings: ILC are well known for their role in epithelial homeostasis and innate immunity. In addition, recent studies identified ILC as architects of intestinal responses to tissue damage after experimental radio and chemotherapy. Group 3 ILC, and their signature cytokine IL-22, can enhance intestinal stem cell regeneration and protect the stem cell niche from damage during experimental HSCT. Moreover, in leukemia patients undergoing HSCT conditioning, appearance of activated group 3 ILC prior to transplant is correlated to reduced incidence of acute GVHD. Summary: ILC have a profound impact on the recovery from tissue damage and severity of GVHD in experimental models. Together with the available data from leukemia patients, this argues for in-depth analysis of the mechanisms of ILC function and the translation of experimental findings to clinical application. Ultimately, control of ILC activation, or of the cytokines they produce, could be employed to reduce GVHD lesion in patients receiving allogeneic HSCT. |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20160503 Date Completed: 20171019 Latest Revision: 20180619 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/MOH.0000000000000262 |
| PMID: | 27135976 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-7048 |
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| DOI: | 10.1097/MOH.0000000000000262 |