دورية أكاديمية
[Design of Novel Carboxamides of Eremomycin and Vancomycin with 4- or 3-Amino Methyl Phenyl Boric Acid and Their Investigation].
| العنوان: | [Design of Novel Carboxamides of Eremomycin and Vancomycin with 4- or 3-Amino Methyl Phenyl Boric Acid and Their Investigation]. |
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| المؤلفون: | Bychkova EN, Korolev AM, Olsufyeva EN, Mirchink EP, Isakova EB |
| المصدر: | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 2015; Vol. 60 (9-10), pp. 7-11. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 8803688 Publication Model: Print Cited Medium: Print ISSN: 0235-2990 (Print) Linking ISSN: 02352990 NLM ISO Abbreviation: Antibiot Khimioter Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Izdatelstvo Meditsina Original Publication: Moskva : Meditsina, c1988- |
| مواضيع طبية MeSH: | Drug Design*, Anti-Bacterial Agents/*chemical synthesis , Boronic Acids/*chemistry , Glycopeptides/*chemical synthesis , Gram-Positive Bacteria/*drug effects , Vancomycin/*analogs & derivatives , Vancomycin/*chemical synthesis, Anti-Bacterial Agents/chemistry ; Dose-Response Relationship, Drug ; Glycopeptides/chemistry ; Microbial Sensitivity Tests ; Molecular Structure ; Vancomycin/chemistry |
| مستخلص: | Amidation of the end carboxyl group of eremomycin and vancomycin by pinacolinic 4- or 3-amino methyl phenyl boron acids esters in the presence of the condensing reagent PyBOP resulted in formation of novel carboxamides of the antibiotics (IIIa-VIa). After elimination of the pinacolinic group under mild hydrolysis in weak acid aqueous medium there formed the respective derivatives with a residue of the nonprotected boric acid (III-VI). It was shown that the activity of the 4-substituted derivatives of the borole-containing eremomycin and vancomycin practically was the same as that of the initial antibiotics, while higher than that of the respective 3-substituted derivatives of the borole-containing derivatives against 8 strains of grampositive bacteria. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Boronic Acids) 0 (Glycopeptides) 110865-90-2 (eremomycin) 6Q205EH1VU (Vancomycin) |
| تواريخ الأحداث: | Date Created: 20160505 Date Completed: 20160609 Latest Revision: 20161020 |
| رمز التحديث: | 20221213 |
| PMID: | 27141632 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0235-2990 |
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