دورية أكاديمية
[The effect of antioxidants on in vivo and in vitro methemoglobin formation in erytrocytes of patients with Parkinson`s disease].
| العنوان: | [The effect of antioxidants on in vivo and in vitro methemoglobin formation in erytrocytes of patients with Parkinson`s disease]. |
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| المؤلفون: | Makletsova MG; Research Center of Neurology, Moscow, Russia., Rikhireva GT; Semenov Institute of Chemical Physics of the Russian Academy Sciences, Moscow, Russia., Poleshuk VV; Research Center of Neurology, Moscow, Russia., Grjakalov KV; Semenov Institute of Chemical Physics of the Russian Academy Sciences, Moscow, Russia., Timerbaeva SL; Research Center of Neurology, Moscow, Russia., Fedorova TN; Research Center of Neurology, Moscow, Russia. |
| المصدر: | Biomeditsinskaia khimiia [Biomed Khim] 2016 Mar-Apr; Vol. 62 (2), pp. 193-7. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk Country of Publication: Russia (Federation) NLM ID: 101196966 Publication Model: Print Cited Medium: Print ISSN: 2310-6972 (Print) Linking ISSN: 23106905 NLM ISO Abbreviation: Biomed Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk, 2003- |
| مواضيع طبية MeSH: | Antioxidants/*pharmacology , Erythrocytes/*drug effects , Methemoglobin/*metabolism , Parkinson Disease/*drug therapy, Acrolein/pharmacology ; Aged ; Benserazide/pharmacology ; Carbidopa/pharmacology ; Carnosine/pharmacology ; Case-Control Studies ; Cells, Cultured ; Drug Combinations ; Electron Spin Resonance Spectroscopy ; Erythrocytes/metabolism ; Female ; Humans ; Levodopa/pharmacology ; Male ; Methemoglobin/drug effects ; Middle Aged ; Parkinson Disease/blood ; Picolines/pharmacology |
| مستخلص: | Methemoglobin formation was examined in erytrocytes of 16 patients with Parkinson`s disease (PD) (stage 3-4 by the Hoehn and Yahr scale). The patients receiving levodopa-containing drugs (madopar, nakom) were also treated with intramuscular injections of mexidol (daily dose 100 mg/day) for 14 days. Control group included 12 clinically healthy persons. The erythrocyte methemoglobin content was determined by electronic paramagnetic resonance (EPR) using the EPR signal intensity with g-factor 6.0. The methemoglobin content was significantly higher in erythrocytes of PD patients than in healthy donors. The complex therapy with mexidol normalized the methemoglobin content in erythrocytes of PD patients. Incubation in vitro of erythrocytes of donors and PD patients with acrolein increased the methemoglobin content, while incubation with carnosine normalized the methemoglobin content in erythrocytes of PD patients. Prophylactic (i.e. before acrolein addition) and therapeutic administration of carnosine to the incubation system with acrolein decreased the methemoglobin content to its initial level. Results of this study suggest that inclusion of the antioxidants mexidol and carnosine in the scheme of basic therapy of PD may reduce side effects associated with methemoglobinemia. |
| فهرسة مساهمة: | Keywords: Parkinson's disease; acrolein; antioxidants; carnosine; methemoglobin; mexidol Local Abstract: [Publisher, Russian] Issledovali 16 bol'nykh s bolezn'iu Parkinsona (BP, 3–4 stadii zabolevaniia po shkale Hoehn-Yahr). Patsienty, nakhodivshiesia na bazovom lechenii levodopa preparatami (madopar, nakom), v techenie 14 dneĭ poluchali meksidol v doze 100 mg/sutki (v/m). Kontrolem sluzhila gruppa iz 12 prakticheski zdorovykh lits. Opredelenie soderzhaniia metgemoglobina v éritrotsitakh provodili s pomoshch'iu metoda élektronnogo paramagnitnogo rezonansa (ÉPR) po intensivnosti signala ÉPR s g-faktorom v oblasti 6.0. V éritrotsitakh bol'nykh s BP vyiavleno znachitel'noe povyshenie soderzhaniia metgemoglobina po sravneniiu s donorami. Kompleksnaia terapiia s meksidolom normalizovala soderzhanie metgemoglobina v éritrotsitakh bol'nykh s BP. Inkubatsiia in vitro éritrotsitov donorov i patsientov s BP s akroleinom privodila k uvelicheniiu soderzhaniia metgemoglobina. Vvedenie karnozina v étikh usloviiakh normalizovalo soderzhanie metgemoglobina. “Profilakticheskoe” (do akroleina) i “terapevticheskoe” vvedenie karnozina v sredu inkubatsii éritrotsitov s akroleinom sposobstvovalo snizheniiu soderzhaniia metgemoglobina do iskhodnogo urovnia. Poluchennye dannye svidetel'stvuiut o tselesoobraznosti vkliucheniia antioksidantov (meksidola i karnozina) v bazovuiu terapiiu BP s tsel'iu snizheniia pobochnykh éffektov, sviazannykh s obrazovaniem metgemoglobina. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Drug Combinations) 0 (Picolines) 0 (benserazide, levodopa drug combination) 0 (carbidopa, levodopa drug combination) 2R985002CT (emoxypine succinate) 46627O600J (Levodopa) 762OS3ZEJU (Benserazide) 7864XYD3JJ (Acrolein) 8HO6PVN24W (Carnosine) 9008-37-1 (Methemoglobin) MNX7R8C5VO (Carbidopa) |
| SCR Disease Name: | Parkinson disease 3 |
| تواريخ الأحداث: | Date Created: 20160505 Date Completed: 20160721 Latest Revision: 20161126 |
| رمز التحديث: | 20240628 |
| DOI: | 10.18097/PBMC20166202193 |
| PMID: | 27143379 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2310-6972 |
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| DOI: | 10.18097/PBMC20166202193 |