دورية أكاديمية
Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012.
| العنوان: | Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012. |
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| المؤلفون: | Donato C; Duke-NUS Medical School, 8 College Rd, Singapore., Hoi le T; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Hoa NT; Department of Clinical Microbiology, Hanoi Medical University, Vietnam., Hoa TM; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Van Duyet L; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Dieu Ngan TT; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Van Kinh N; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Vu Trung N; National Hospital of Tropical Diseases, 78 Giai Phong Street, Hanoi, Vietnam., Vijaykrishna D; Duke-NUS Medical School, 8 College Rd, Singapore; Department of Pathology, Singapore General Hospital, Singapore. Electronic address: vijay.dhanasekaran@duke-nus.edu.sg. |
| المصدر: | Virology [Virology] 2016 Aug; Vol. 495, pp. 1-9. Date of Electronic Publication: 2016 May 03. |
| نوع المنشور: | Historical Article; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Genotype*, Enterovirus A, Human/*classification , Enterovirus A, Human/*genetics , Enterovirus Infections/*epidemiology , Enterovirus Infections/*virology, Age Distribution ; Capsid Proteins/genetics ; Child ; Child, Preschool ; Disease Outbreaks ; Enterovirus Infections/history ; Genome, Viral ; Geography, Medical ; Hand, Foot and Mouth Disease/epidemiology ; Hand, Foot and Mouth Disease/virology ; History, 21st Century ; Hospitalization ; Humans ; Infant ; Phylogeny ; Seasons ; Vietnam/epidemiology |
| مستخلص: | Background: Enterovirus 71 subgenogroup C4 caused the largest outbreak of Hand, Foot and Mouth Disease (HFMD) in Vietnam during 2011-2012, resulting in over 200,000 hospitalisations and 207 fatalities. Methods: A total of 1917 samples with adequate volume for RT-PCR analysis were collected from patients hospitalised with HFMD throughout Vietnam and 637 were positive for EV71. VP1 gene (n=87) and complete genome (n=9) sequencing was performed. Maximum-likelihood phylogenetic analysis was performed to characterise the B5, C4 and C5 strains detected. Results: Sequence analyses revealed that the dominant subgenogroup associated with the 2012 outbreak was C4, with B5 and C5 strains representing a small proportion of these cases. Conclusions: Numerous countries in the region including Malaysia, Taiwan and China have a large influence on strain diversity in Vietnam and understanding the transmission of EV71 throughout Southeast Asia is vital to inform preventative public health measures and vaccine development efforts. (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: C4 subgenogroup; Enterovirus 71; Outbreak; Phylogenetics; Vietnam |
| المشرفين على المادة: | 0 (Capsid Proteins) |
| تواريخ الأحداث: | Date Created: 20160506 Date Completed: 20170504 Latest Revision: 20171219 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.virol.2016.04.026 |
| PMID: | 27148893 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1096-0341 |
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| DOI: | 10.1016/j.virol.2016.04.026 |