دورية أكاديمية
أعرض في EDS

Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity.

التفاصيل البيبلوغرافية
العنوان: Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity.
المؤلفون: Tramullas M; APC Microbiome Institute, University College Cork, Cork, Ireland., Finger BC; School of Pharmacy, University College Cork, Cork, Ireland., Dinan TG; APC Microbiome Institute, University College Cork, Cork, Ireland.; Department of Psychiatry & Neurobehavioural Science, University College Cork, Cork, Ireland., Cryan JF; APC Microbiome Institute, University College Cork, Cork, Ireland.; Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.
المصدر: PloS one [PLoS One] 2016 May 09; Vol. 11 (5), pp. e0155367. Date of Electronic Publication: 2016 May 09 (Print Publication: 2016).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Diet, High-Fat*, Obesity/*physiopathology , Toll-Like Receptor 4/*physiology , Visceral Pain/*physiopathology, Animals ; Brain/physiopathology ; Male ; Mice ; Mice, Inbred C57BL
مستخلص: Exposure to high-fat diet induces both, peripheral and central alterations in TLR4 expression. Moreover, functional TLR4 is required for the development of high-fat diet-induced obesity. Recently, central alterations in TLR4 expression have been associated with the modulation of visceral pain. However, it remains unknown whether there is a functional interaction between the role of TLR4 in diet-induced obesity and in visceral pain. In the present study we investigated the impact of long-term exposure to high-fat diet on visceral pain perception and on the levels of TLR4 and Cd11b (a microglial cell marker) protein expression in the prefrontal cortex (PFC) and hippocampus. Peripheral alterations in TLR4 were assessed following the stimulation of spleenocytes with the TLR4-agonist LPS. Finally, we evaluated the effect of blocking TLR4 on visceral nociception, by administering TAK-242, a selective TLR4-antagonist. Our results demonstrated that exposure to high-fat diet induced visceral hypersensitivity. In parallel, enhanced TLR4 expression and microglia activation were found in brain areas related to visceral pain, the PFC and the hippocampus. Likewise, peripheral TLR4 activity was increased following long-term exposure to high-fat diet, resulting in an increased level of pro-inflammatory cytokines. Finally, TLR4 blockage counteracted the hyperalgesic phenotype present in mice fed on high-fat diet. Our data reveal a role for TLR4 in visceral pain modulation in a model of diet-induced obesity, and point to TLR4 as a potential therapeutic target for the development of drugs to treat visceral hypersensitivity present in pathologies associated to fat diet consumption.
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المشرفين على المادة: 0 (Toll-Like Receptor 4)
تواريخ الأحداث: Date Created: 20160510 Date Completed: 20170726 Latest Revision: 20190219
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4861320
DOI: 10.1371/journal.pone.0155367
PMID: 27159520
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0155367