دورية أكاديمية
أعرض في EDS

Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.

التفاصيل البيبلوغرافية
العنوان: Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.
المؤلفون: Villaume MT; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Sella E; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Saul G; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Borzilleri RM; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Fargnoli J; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Johnston KA; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Zhang H; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Fereshteh MP; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Dhar TG; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Baran PS; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
المصدر: ACS central science [ACS Cent Sci] 2016 Jan 27; Vol. 2 (1), pp. 27-31. Date of Electronic Publication: 2015 Dec 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington DC : ACS Publications, [2015]-
مستخلص: The fungal-derived Taiwanese natural product antroquinonol A has attracted both academic and commercial interest due to its reported exciting biological properties. This reduced quinone is currently in phase II trials (USA and Taiwan) for the treatment of non-small-cell lung carcinoma (NSCLC) and was recently granted orphan drug status by the FDA for the treatment of pancreatic cancer and acute myeloid leukemia. Pending successful completion of human clinical trials, antroquinonol is expected to be commercialized under the trade name Hocena. A synthesis-enabled biological re-examination of this promising natural product, however, reveals minimal in vitro and in vivo antitumor activity in preclinical models.
References: Org Biomol Chem. 2015 May 21;13(19):5510-9. (PMID: 25875221)
Arthritis Rheum. 2012 Jan;64(1):232-42. (PMID: 21905011)
Org Lett. 2015 Mar 6;17(5):1138-41. (PMID: 25679542)
J Nat Prod. 2014 Apr 25;77(4):1061-4. (PMID: 24593224)
Free Radic Biol Med. 2013 Aug;61:285-97. (PMID: 23567192)
Acc Chem Res. 2015 Mar 17;48(3):712-21. (PMID: 25702529)
Br J Pharmacol. 2015 Jan;172(1):38-49. (PMID: 24977411)
Biomed Pharmacother. 2014 Oct;68(8):1007-14. (PMID: 25312820)
Mutat Res. 2011 Feb 10;707(1-2):42-52. (PMID: 21185843)
Planta Med. 2007 Oct;73(13):1412-5. (PMID: 17932820)
Food Chem Toxicol. 2015 Apr;78:33-41. (PMID: 25656647)
Biochem Pharmacol. 2010 Jan 15;79(2):162-71. (PMID: 19723512)
J Nutr Biochem. 2012 Aug;23(8):900-7. (PMID: 21840189)
J Ethnopharmacol. 2011 Jun 14;136(1):168-77. (PMID: 21540101)
J Org Chem. 2015 Jun 19;80(12):6044-51. (PMID: 26039178)
Org Lett. 2009 Nov 19;11(22):5330-3. (PMID: 19860385)
Angew Chem Int Ed Engl. 2009;48(28):5143-7. (PMID: 19526480)
Free Radic Biol Med. 2011 Jun 1;50(11):1503-16. (PMID: 21376112)
J Am Chem Soc. 2004 Feb 18;126(6):1624-5. (PMID: 14871080)
Beilstein J Org Chem. 2008;4:37. (PMID: 19043623)
تواريخ الأحداث: Date Created: 20160511 Date Completed: 20160510 Latest Revision: 20200930
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4827469
DOI: 10.1021/acscentsci.5b00345
PMID: 27163023
قاعدة البيانات: MEDLINE
الوصف
تدمد:2374-7943
DOI:10.1021/acscentsci.5b00345