دورية أكاديمية
أعرض في EDS

Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study.

التفاصيل البيبلوغرافية
العنوان: Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study.
المؤلفون: Wallace IR; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK.; Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK., McKinley MC; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., McEvoy CT; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Hamill LL; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Ennis CN; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., McGinty A; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Bell PM; Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK., Patterson CC; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Woodside JV; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Young IS; Centre for Public Health, Queen's University Belfast, Institute of Clinical Science B, Belfast, UK., Hunter SJ; Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK.
المصدر: Clinical endocrinology [Clin Endocrinol (Oxf)] 2016 Sep; Vol. 85 (3), pp. 386-92. Date of Electronic Publication: 2016 Jun 13.
نوع المنشور: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: Oxford : Blackwell Publishing
Original Publication: Oxford, Blackwell Scientific Publications.
مواضيع طبية MeSH: Vitamin D/*analogs & derivatives, Cardiovascular Diseases ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Humans ; Insulin Resistance ; Middle Aged ; Overweight ; Vitamin D/blood
مستخلص: Context: In observational studies, low serum 25-hydroxyvitamin D (25-OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25-OHD may have beneficial effects on insulin resistance or beta-cell function. Cross-sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25-OHD concentration provide conflicting results.
Objective: This study examined the relationship between serum 25-OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.
Methods: A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m(2) ), underwent assessments of insulin sensitivity (two-step euglycaemic hyperinsulinaemic clamp, HOMA2-IR), beta-cell function (HOMA2%B), serum 25-OHD concentration and body composition (DEXA).
Results: Mean total 25-OHD concentration was 32·2, range 21·8-46·6 nmol/l. No association was demonstrated between serum 25-OHD concentration and insulin resistance.
Conclusions: In this study using optimal assessment techniques to measure 25-OHD concentration, insulin sensitivity and body composition, there was no association between serum 25-OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25-OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25-OHD concentration and insulin resistance.
(© 2016 John Wiley & Sons Ltd.)
معلومات مُعتمدة: G0901530 United Kingdom MRC_ Medical Research Council; MR/J000388/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health
سلسلة جزيئية: ClinicalTrials.gov NCT00874341
المشرفين على المادة: 1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
تواريخ الأحداث: Date Created: 20160514 Date Completed: 20170922 Latest Revision: 20220129
رمز التحديث: 20221213
DOI: 10.1111/cen.13100
PMID: 27175553
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2265
DOI:10.1111/cen.13100