دورية أكاديمية
Sperm Capacitation and Acrosome Reaction in Mammalian Sperm.
| العنوان: | Sperm Capacitation and Acrosome Reaction in Mammalian Sperm. |
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| المؤلفون: | Stival C; Instituto de Biología Molecular y Celular de Rosario (CONICET-UNR) and Laboratorio de Especialidades Reproductivas (Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), 2000, Rosario, Argentina., Puga Molina Ldel C; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina., Paudel B; Department of Veterinary and Animal Sciences, ISB, University of Massachusetts, 01003, Amherst, MA, USA., Buffone MG; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina., Visconti PE; Department of Veterinary and Animal Sciences, ISB, University of Massachusetts, 01003, Amherst, MA, USA., Krapf D; Instituto de Biología Molecular y Celular de Rosario (CONICET-UNR) and Laboratorio de Especialidades Reproductivas (Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), 2000, Rosario, Argentina. krapf@ibr-conicet.gov.ar. |
| المصدر: | Advances in anatomy, embryology, and cell biology [Adv Anat Embryol Cell Biol] 2016; Vol. 220, pp. 93-106. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0407712 Publication Model: Print Cited Medium: Print ISSN: 0301-5556 (Print) Linking ISSN: 03015556 NLM ISO Abbreviation: Adv Anat Embryol Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Acrosome Reaction/*physiology , Cell Membrane/*metabolism , Sperm Capacitation/*physiology , Spermatozoa/*physiology, Animals ; Cell Membrane Permeability ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gene Expression Regulation ; Ion Transport ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Male ; Mammals ; Phosphorylation ; Signal Transduction ; Spermatozoa/cytology |
| مستخلص: | Physiological changes that endow mammalian sperm with fertilizing capacity are known as sperm capacitation. As part of capacitation, sperm develop an asymmetrical flagellar beating known as hyperactivation and acquire the ability to undergo the acrosome reaction. Together, these processes promote fertilizing competence in sperm. At the molecular level, capacitation involves a series of signal transduction events which include activation of cAMP-dependent phosphorylation pathways, removal of cholesterol, hyperpolarization of the sperm plasma membrane, and changes in ion permeability. In recent years, new technologies have aided in the study of sperm signaling molecules with better resolution, at both spatial and temporal levels, unraveling how different cascades integrate and cooperate to render a fertilizing sperm. Despite this new information, the molecular mechanisms connecting capacitation with acrosomal exocytosis and hyperactivation are not well understood. This review brings together results obtained in mammalian species in the field of sperm capacitation with special focus on those pathways involved in the preparation to undergo the acrosomal reaction. |
| معلومات مُعتمدة: | HD038082 United States HD NICHD NIH HHS; R01-TW008662 United States TW FIC NIH HHS; R01HD44044 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 0 (Kcnu1 protein, mouse) 0 (Large-Conductance Calcium-Activated Potassium Channels) E0399OZS9N (Cyclic AMP) EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases) |
| تواريخ الأحداث: | Date Created: 20160520 Date Completed: 20160818 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/978-3-319-30567-7_5 |
| PMID: | 27194351 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0301-5556 |
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| DOI: | 10.1007/978-3-319-30567-7_5 |