دورية أكاديمية
أعرض في EDS

CIS is a potent checkpoint in NK cell-mediated tumor immunity.

التفاصيل البيبلوغرافية
العنوان: CIS is a potent checkpoint in NK cell-mediated tumor immunity.
المؤلفون: Delconte RB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Kolesnik TB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Shi W; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Putz EM; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Stannard K; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Zhang JG; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Teh C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Firth M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Ushiki T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Andoniou CE; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Degli-Esposti MA; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Sharp PP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Sanvitale CE; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Infusini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Liau NP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Linossi EM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Burns CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Carotta S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Gray DH; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Seillet C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Hutchinson DS; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Belz GT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Webb AI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Alexander WS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Li SS; Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada., Bullock AN; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Babon JJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Smyth MJ; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; School of Medicine, University of Queensland, Herston, Queensland, Australia., Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia.
المصدر: Nature immunology [Nat Immunol] 2016 Jul; Vol. 17 (7), pp. 816-24. Date of Electronic Publication: 2016 May 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature America Inc. c2000-
مواضيع طبية MeSH: Immunotherapy/*methods , Killer Cells, Natural/*immunology , Neoplasms/*therapy , Suppressor of Cytokine Signaling Proteins/*metabolism, Animals ; Cell Proliferation/genetics ; Cytotoxicity, Immunologic/genetics ; Immunologic Surveillance ; Interferon-gamma/metabolism ; Interleukin-15/metabolism ; Janus Kinase 1/metabolism ; Lymphocyte Activation/genetics ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Targeted Therapy ; Neoplasms/immunology ; Signal Transduction/genetics ; Suppressor of Cytokine Signaling Proteins/genetics
مستخلص: The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ production and cytotoxicity toward tumors. This was associated with increased JAK-STAT signaling in NK cells in which Cish was deleted. Correspondingly, CIS interacted with the tyrosine kinase JAK1, inhibiting its enzymatic activity and targeting JAK for proteasomal degradation. Cish(-/-) mice were resistant to melanoma, prostate and breast cancer metastasis in vivo, and this was intrinsic to NK cell activity. Our data uncover a potent intracellular checkpoint in NK cell-mediated tumor immunity and suggest possibilities for new cancer immunotherapies directed at blocking CIS function.
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Comment in: Nat Immunol. 2016 Jun 21;17(7):746-7. (PMID: 27327996)
Erratum in: Nat Immunol. 2023 Dec 12;:. (PMID: 38087084)
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معلومات مُعتمدة: Canada CIHR; 092809/Z/10/Z United Kingdom Wellcome Trust
المشرفين على المادة: 0 (Interleukin-15)
0 (Suppressor of Cytokine Signaling Proteins)
0 (cytokine inducible SH2-containing protein)
82115-62-6 (Interferon-gamma)
EC 2.7.10.2 (JAK1 protein, human)
EC 2.7.10.2 (Janus Kinase 1)
تواريخ الأحداث: Date Created: 20160524 Date Completed: 20170531 Latest Revision: 20231212
رمز التحديث: 20240628
DOI: 10.1038/ni.3470
PMID: 27213690
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-2916
DOI:10.1038/ni.3470