دورية أكاديمية
CIS is a potent checkpoint in NK cell-mediated tumor immunity.
العنوان: | CIS is a potent checkpoint in NK cell-mediated tumor immunity. |
---|---|
المؤلفون: | Delconte RB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Kolesnik TB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Shi W; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Putz EM; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Stannard K; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Zhang JG; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Teh C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Firth M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Ushiki T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Andoniou CE; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Degli-Esposti MA; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Sharp PP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Sanvitale CE; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Infusini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Liau NP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Linossi EM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Burns CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Carotta S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Gray DH; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Seillet C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Hutchinson DS; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Belz GT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Webb AI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Alexander WS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Li SS; Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada., Bullock AN; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Babon JJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Smyth MJ; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; School of Medicine, University of Queensland, Herston, Queensland, Australia., Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia. |
المصدر: | Nature immunology [Nat Immunol] 2016 Jul; Vol. 17 (7), pp. 816-24. Date of Electronic Publication: 2016 May 23. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
مواضيع طبية MeSH: | Immunotherapy/*methods , Killer Cells, Natural/*immunology , Neoplasms/*therapy , Suppressor of Cytokine Signaling Proteins/*metabolism, Animals ; Cell Proliferation/genetics ; Cytotoxicity, Immunologic/genetics ; Immunologic Surveillance ; Interferon-gamma/metabolism ; Interleukin-15/metabolism ; Janus Kinase 1/metabolism ; Lymphocyte Activation/genetics ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Targeted Therapy ; Neoplasms/immunology ; Signal Transduction/genetics ; Suppressor of Cytokine Signaling Proteins/genetics |
مستخلص: | The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ production and cytotoxicity toward tumors. This was associated with increased JAK-STAT signaling in NK cells in which Cish was deleted. Correspondingly, CIS interacted with the tyrosine kinase JAK1, inhibiting its enzymatic activity and targeting JAK for proteasomal degradation. Cish(-/-) mice were resistant to melanoma, prostate and breast cancer metastasis in vivo, and this was intrinsic to NK cell activity. Our data uncover a potent intracellular checkpoint in NK cell-mediated tumor immunity and suggest possibilities for new cancer immunotherapies directed at blocking CIS function. |
التعليقات: | Comment in: Nat Rev Immunol. 2016 Jul;16(7):402-3. (PMID: 27265596) Comment in: Nat Immunol. 2016 Jun 21;17(7):746-7. (PMID: 27327996) Erratum in: Nat Immunol. 2023 Dec 12;:. (PMID: 38087084) |
References: | Nature. 2014 Nov 27;515(7528):563-7. (PMID: 25428504) Cytokine Growth Factor Rev. 2013 Jun;24(3):241-8. (PMID: 23545160) Methods Mol Biol. 2013;967:235-48. (PMID: 23296734) PLoS One. 2013 Aug 21;8(8):e70536. (PMID: 23990909) Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9. (PMID: 9419338) Semin Oncol. 2015 Aug;42(4):539-48. (PMID: 26320059) EMBO J. 1995 Jun 15;14(12):2816-26. (PMID: 7796808) Nat Rev Immunol. 2007 Sep;7(9):703-14. (PMID: 17717540) Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7142-7. (PMID: 21482773) Nat Commun. 2014 Aug 14;5:4539. (PMID: 25119382) Semin Immunol. 2014 Apr;26(2):161-72. (PMID: 24618042) Nat Immunol. 2007 Aug;8(8):856-63. (PMID: 17618288) N Engl J Med. 2012 Jun 28;366(26):2443-54. (PMID: 22658127) Nature. 2002 Jun 27;417(6892):949-54. (PMID: 12068308) Blood. 1997 May 1;89(9):3148-54. (PMID: 9129017) Mol Cell Proteomics. 2014 Sep;13(9):2513-26. (PMID: 24942700) Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. (PMID: 10051596) N Engl J Med. 2015 May 21;372(21):2006-17. (PMID: 25891304) Nat Immunol. 2014 May;15(5):431-8. (PMID: 24658051) Nat Immunol. 2013 Jul;14(7):732-40. (PMID: 23727894) Blood. 1995 Nov 15;86(10):3698-704. (PMID: 7579336) Cancer Immunol Res. 2015 Nov;3(11):1207-17. (PMID: 26198985) Clin Cancer Res. 2013 Oct 15;19(20):5626-35. (PMID: 23983257) Science. 2011 Mar 25;331(6024):1565-70. (PMID: 21436444) Transplant Proc. 2012 May;44(4):1032-4. (PMID: 22564618) Proc Natl Acad Sci U S A. 2006 May 16;103(20):7637-42. (PMID: 16675548) Nat Rev Immunol. 2012 Mar 22;12(4):239-52. (PMID: 22437937) EMBO J. 1999 Mar 1;18(5):1309-20. (PMID: 10064597) Sci Transl Med. 2014 Mar 19;6(228):228ra37. (PMID: 24648340) J Exp Med. 2008 Dec 22;205(13):2965-73. (PMID: 19029380) N Engl J Med. 2010 Aug 19;363(8):711-23. (PMID: 20525992) N Engl J Med. 2011 Jun 30;364(26):2517-26. (PMID: 21639810) Dis Model Mech. 2015 Mar;8(3):237-51. (PMID: 25633981) J Proteome Res. 2011 Apr 1;10(4):1794-805. (PMID: 21254760) Cancer Res. 2014 Dec 15;74(24):7298-308. (PMID: 25351955) Nat Biotechnol. 2008 Dec;26(12):1367-72. (PMID: 19029910) Immunity. 2012 Feb 24;36(2):239-50. (PMID: 22342841) Mol Cell Proteomics. 2015 Jan;14(1):120-35. (PMID: 25363814) Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9. (PMID: 22021440) J Exp Med. 2015 Nov 16;212(12):2095-113. (PMID: 26527801) Nat Rev Cancer. 2016 Feb;16(2):121-6. (PMID: 26822578) Nat Methods. 2009 May;6(5):359-62. (PMID: 19377485) Br J Cancer. 2015 Apr 28;112(9):1421-7. (PMID: 25856776) Cancer Discov. 2016 Apr;6(4):446-59. (PMID: 26787820) Immunol Cell Biol. 2014 Mar;92(3):210-3. (PMID: 24492800) J Immunol. 2007 Jun 15;178(12):7540-9. (PMID: 17548588) N Engl J Med. 2015 Jul 2;373(1):23-34. (PMID: 26027431) Cell. 1999 Sep 3;98 (5):597-608. (PMID: 10490099) J Immunol. 2006 Apr 15;176(8):4834-42. (PMID: 16585578) Methods Mol Biol. 2013;967:39-55. (PMID: 23296720) Cancer Res. 2011 Apr 15;71(8):2892-900. (PMID: 21292811) Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92. (PMID: 19762238) J Biol Chem. 1999 Oct 15;274(42):30266-72. (PMID: 10514520) N Engl J Med. 2012 Jun 28;366(26):2455-65. (PMID: 22658128) Nat Immunol. 2003 Jun;4(6):540-5. (PMID: 12754505) Nat Struct Mol Biol. 2013 Apr;20(4):469-76. (PMID: 23454976) Methods Mol Biol. 2009;570:67-76. (PMID: 19649589) Curr Opin Immunol. 2015 Apr;33:23-35. (PMID: 25621841) |
معلومات مُعتمدة: | Canada CIHR; 092809/Z/10/Z United Kingdom Wellcome Trust |
المشرفين على المادة: | 0 (Interleukin-15) 0 (Suppressor of Cytokine Signaling Proteins) 0 (cytokine inducible SH2-containing protein) 82115-62-6 (Interferon-gamma) EC 2.7.10.2 (JAK1 protein, human) EC 2.7.10.2 (Janus Kinase 1) |
تواريخ الأحداث: | Date Created: 20160524 Date Completed: 20170531 Latest Revision: 20231212 |
رمز التحديث: | 20240628 |
DOI: | 10.1038/ni.3470 |
PMID: | 27213690 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1529-2916 |
---|---|
DOI: | 10.1038/ni.3470 |