دورية أكاديمية
Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation.
| العنوان: | Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation. |
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| المؤلفون: | O'Shea NR; Division of Medicine, University College London, London, UK., Chew TS; Division of Medicine, University College London, London, UK., Dunne J; Division of Medicine, University College London, London, UK., Marnane R; Division of Medicine, University College London, London, UK., Nedjat-Shokouhi B; Division of Medicine, University College London, London, UK., Smith PJ; Division of Medicine, University College London, London, UK., Bloom SL; Department of Gastroenterology, University College London Hospital, UK., Smith AM; Division of Medicine, University College London, London, UK.; Microbial Diseases, Eastman Dental Institute, University College London, London, UK., Segal AW; Division of Medicine, University College London, London, UK. |
| المصدر: | Journal of Crohn's & colitis [J Crohns Colitis] 2016 Dec; Vol. 10 (12), pp. 1417-1427. Date of Electronic Publication: 2016 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford : Oxford University Press Original Publication: Amsterdam : Elsevier Science |
| مواضيع طبية MeSH: | ADAM Proteins/*physiology , Colitis/*physiopathology, ADAM Proteins/metabolism ; Animals ; Citrobacter rodentium ; Colitis/immunology ; Colon/immunology ; Colon/physiopathology ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Enterobacteriaceae Infections/complications ; Intestinal Mucosa/immunology ; Intestinal Mucosa/physiopathology ; Mice ; Mice, Inbred C57BL ; Salmonella Infections, Animal/complications ; Salmonella typhimurium |
| مستخلص: | Background and Aims: ADAM [A Disintegrin And Metalloproteinase] is a family of peptidase proteins which have diverse roles in tissue homeostasis and immunity. Here, we study ADAM-like DECysin-1 [ADAMDEC1] a unique member of the ADAM family. ADAMDEC1 expression is restricted to the macrophage/dendritic cell populations of the gastrointestinal tract and secondary lymphoid tissue. The biological function of ADAMDEC1 is unknown but it has been hypothesised to play a role in immunity. The identification of reduced ADAMDEC1 expression in Crohn's disease patients has provided evidence of a potential role in bowel inflammation. Methods: Adamdec1 -/- mice were exposed to dextran sodium sulphate or infected orally with Citrobacter rodentium or Salmonella typhimurium. The clinical response was monitored. Results: The loss of Adamdec1 rendered mice more susceptible to the induction of bacterial and chemical induced colitis, as evidenced by increased neutrophil infiltration, greater IL-6 and IL-1β secretion, more weight loss and increased mortality. In the absence of Adamdec1, greater numbers of Citrobacter rodentium were found in the spleen, suggestive of a breakdown in mucosal immunity which resulted in bacteraemia. Conclusion: In summary, ADAMDEC1 protects the bowel from chemical and bacterial insults, failure of which may predispose to Crohn's disease. (© European Crohn’s and Colitis Organisation 2016.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; G0902005 United Kingdom MRC_ Medical Research Council; G0902022 United Kingdom MRC_ Medical Research Council; MR/L000261/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Citrobacter rodentium; DSS; colitis |
| المشرفين على المادة: | 9042-14-2 (Dextran Sulfate) EC 3.4.24.- (ADAM Proteins) EC 3.4.24.- (Adamdec1 protein, mouse) EC 3.4.24.- (decysin) |
| تواريخ الأحداث: | Date Created: 20160527 Date Completed: 20170602 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| مُعرف محوري في PubMed: | PMC5174729 |
| DOI: | 10.1093/ecco-jcc/jjw111 |
| PMID: | 27226416 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-4479 |
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| DOI: | 10.1093/ecco-jcc/jjw111 |