دورية أكاديمية
أعرض في EDS

Breast tumor response to ultrasound mediated excitation of microbubbles and radiation therapy in vivo.

التفاصيل البيبلوغرافية
العنوان: Breast tumor response to ultrasound mediated excitation of microbubbles and radiation therapy in vivo.
المؤلفون: Lai P; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Tarapacki C; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Tran WT; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., El Kaffas A; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Lee J; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Hupple C; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Iradji S; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Giles A; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Al-Mahrouki A; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Czarnota GJ; Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
المصدر: Oncoscience [Oncoscience] 2016 Mar 24; Vol. 3 (3-4), pp. 98-108. Date of Electronic Publication: 2016 Mar 24 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Impact Journals LLC Country of Publication: United States NLM ID: 101636666 Publication Model: eCollection Cited Medium: Print ISSN: 2331-4737 (Print) Linking ISSN: 23314737 NLM ISO Abbreviation: Oncoscience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York : Impact Journals LLC, [2014]-
مستخلص: Acoustically stimulated microbubbles have been demonstrated to perturb endothelial cells of the vasculature resulting in biological effects. In the present study, vascular and tumor response to ultrasound-stimulated microbubble and radiation treatment was investigated in vivo to identify effects on the blood vessel endothelium. Mice bearing breast cancer tumors (MDA-MB-231) were exposed to ultrasound after intravenous injection of microbubbles at different concentrations, and radiation at different doses (0, 2, and 8 Gy). Mice were sacrificed 12 and 24 hours after treatment for histopathological analysis. Tumor growth delay was assessed for up to 28 days after treatment. The results demonstrated additive antitumor and antivascular effects when ultrasound stimulated microbubbles were combined with radiation. Results indicated tumor cell apoptosis, vascular leakage, a decrease in tumor vasculature, a delay in tumor growth and an overall tumor disruption. When coupled with radiation, ultrasound-stimulated microbubbles elicited synergistic anti-tumor and antivascular effects by acting as a radioenhancing agent in breast tumor blood vessels. The present study demonstrates ultrasound driven microbubbles as a novel form of targeted antiangiogenic therapy in a breast cancer xenograft model that can potentiate additive effects to radiation in vivo.
التعليقات: Erratum in: Oncoscience. 2017 Jan 30;4(1-2):14. (PMID: 28484729)
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فهرسة مساهمة: Keywords: Microbubbles; breast neoplasm; high frequency ultrasound; microvasculature; radiation
تواريخ الأحداث: Date Created: 20160527 Date Completed: 20160526 Latest Revision: 20200929
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4872648
DOI: 10.18632/oncoscience.299
PMID: 27226983
قاعدة البيانات: MEDLINE
الوصف
تدمد:2331-4737
DOI:10.18632/oncoscience.299