دورية أكاديمية
Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain.
| العنوان: | Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain. |
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| المؤلفون: | Hansen F; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil. Electronic address: fernandahansen@hotmail.com., Pandolfo P; Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141 Niterói, RJ, Brazil., Galland F; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil., Torres FV; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil., Dutra MF; Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Trindade, 88040-970 Florianópolis, SC, Brazil., Batassini C; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil., Guerra MC; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil., Leite MC; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil., Gonçalves CA; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil. |
| المصدر: | Physiology & behavior [Physiol Behav] 2016 Oct 01; Vol. 164 (Pt A), pp. 93-101. Date of Electronic Publication: 2016 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York NY : Elsevier Science Original Publication: Oxford, Eng., Long Island City, Pergamon Press. |
| مواضيع طبية MeSH: | Brain/*drug effects , Brain/*metabolism , Cognition Disorders/*chemically induced , Pyruvaldehyde/*toxicity, Analysis of Variance ; Animals ; Anxiety/etiology ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Glutamate-Ammonia Ligase/metabolism ; Glutamic Acid/metabolism ; Glutathione/metabolism ; In Vitro Techniques ; Infusions, Intraventricular ; Locomotion ; Male ; Maze Learning/drug effects ; Rats ; Rats, Wistar ; Recognition, Psychology/drug effects ; S100 Calcium Binding Protein beta Subunit/metabolism ; Time Factors ; rab GTP-Binding Proteins/metabolism |
| مستخلص: | Diabetes is associated with loss of cognitive function and increased risk for Alzheimer's disease (AD). Advanced glycation end products (AGEs) are elevated in diabetes and AD and have been suggested to act as mediators of the cognitive decline observed in these pathologies. Methylglyoxal (MG) is an extremely reactive carbonyl compound that propagates glycation reactions and is, therefore, able to generate AGEs. Herein, we evaluated persistent behavioral and biochemical parameters to explore the hypothesis that elevated exogenous MG concentrations, induced by intracerebroventricular (ICV) infusion, lead to cognitive decline in Wistar rats. A high and sustained administration of MG (3μmol/μL; subdivided into 6days) was found to decrease the recognition index of rats, as evaluated by the object-recognition test. However, MG was unable to impair learning-memory processes, as shown by the habituation in the open field (OF) and Y-maze tasks. Moreover, a single high dose of MG induced persistent alterations in anxiety-related behavior, diminishing the anxiety-like parameters evaluated in the OF test. Importantly, MG did not alter locomotion behavior in the different tasks performed. Our biochemical findings support the hypothesis that MG induces persistent alterations in the hippocampus, but not in the cortex, related to glyoxalase 1 activity, AGEs content and glutamate uptake. Glial fibrillary acidic protein and S100B content, as well as S100B secretion (astroglial-related parameters of brain injury), were not altered by ICV MG administration. Taken together, our data suggest that MG interferes directly in brain function and that the time and the levels of exogenous MG determine the different features that can be seen in diabetic patients. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Advanced glycation end products; Anxiety; Dementia; Diabetes; Glyoxalase 1; Methylglyoxal |
| المشرفين على المادة: | 0 (Glial Fibrillary Acidic Protein) 0 (S100 Calcium Binding Protein beta Subunit) 3KX376GY7L (Glutamic Acid) 722KLD7415 (Pyruvaldehyde) EC 3.6.5.2 (rab GTP-Binding Proteins) EC 6.3.1.2 (Glutamate-Ammonia Ligase) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 20160529 Date Completed: 20170619 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.physbeh.2016.05.046 |
| PMID: | 27235733 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-507X |
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| DOI: | 10.1016/j.physbeh.2016.05.046 |