دورية أكاديمية
أعرض في EDS

Stem cells, growth factors and scaffolds in craniofacial regenerative medicine.

التفاصيل البيبلوغرافية
العنوان: Stem cells, growth factors and scaffolds in craniofacial regenerative medicine.
المؤلفون: Tollemar V; The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA; Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA; Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Collier ZJ; The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA; Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA., Mohammed MK; The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA; Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA., Lee MJ; Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA., Ameer GA; Department of Surgery, Feinberg School of Medicine, Chicago, IL 60611, USA; Biomedical Engineering Department, Northwestern University, Evanston, IL 60208., Reid RR; Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL 60637, USA.
المصدر: Genes & diseases [Genes Dis] 2016 Mar; Vol. 3 (1), pp. 56-71. Date of Electronic Publication: 2015 Oct 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of KeAi Communications Co. Ltd Country of Publication: Netherlands NLM ID: 101635967 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2352-4820 (Print) Linking ISSN: 23523042 NLM ISO Abbreviation: Genes Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Amsterdam] : Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
Original Publication: Chongqing, China : Chongqing Medical University, [2014]-
مستخلص: Current reconstructive approaches to large craniofacial skeletal defects are often complicated and challenging. Critical-sized defects are unable to heal via natural regenerative processes and require surgical intervention, traditionally involving autologous bone (mainly in the form of nonvascularized grafts) or alloplasts. Autologous bone grafts remain the gold standard of care in spite of the associated risk of donor site morbidity. Tissue engineering approaches represent a promising alternative that would serve to facilitate bone regeneration even in large craniofacial skeletal defects. This strategy has been tested in a myriad of iterations by utilizing a variety of osteoconductive scaffold materials, osteoblastic stem cells, as well as osteoinductive growth factors and small molecules. One of the major challenges facing tissue engineers is creating a scaffold fulfilling the properties necessary for controlled bone regeneration. These properties include osteoconduction, osetoinduction, biocompatibility, biodegradability, vascularization, and progenitor cell retention. This review will provide an overview of how optimization of the aforementioned scaffold parameters facilitates bone regenerative capabilities as well as a discussion of common osteoconductive scaffold materials.
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معلومات مُعتمدة: K08 DE020140 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: Scaffolds; bone regeneration; craniofacial defects; osteogenesis; regenerative medicine; tissue engineering
تواريخ الأحداث: Date Created: 20160531 Latest Revision: 20240331
رمز التحديث: 20240331
مُعرف محوري في PubMed: PMC4880030
DOI: 10.1016/j.gendis.2015.09.004
PMID: 27239485
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-4820
DOI:10.1016/j.gendis.2015.09.004