دورية أكاديمية
(18)F-fluoride-PET for dynamic in vivo monitoring of bone formation in multiple myeloma.
| العنوان: | (18)F-fluoride-PET for dynamic in vivo monitoring of bone formation in multiple myeloma. |
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| المؤلفون: | Regelink JC; Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands. jc.regelink@meandermc.nl.; Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands. jc.regelink@meandermc.nl., Raijmakers PG; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., Bravenboer N; Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands., Milek R; Janssen-Cilag B.V., Tilburg, The Netherlands., Hoetjes NJ; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., de Kreuk AM; Department of Internal Medicine, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands., van Duin M; Department of Haematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Wondergem MJ; Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands., Lips P; Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands., Sonneveld P; Department of Haematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Zijlstra JM; Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands., Zweegman S; Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands. |
| المصدر: | EJNMMI research [EJNMMI Res] 2016 Dec; Vol. 6 (1), pp. 46. Date of Electronic Publication: 2016 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Berlin Country of Publication: Germany NLM ID: 101560946 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2191-219X (Print) Linking ISSN: 2191219X NLM ISO Abbreviation: EJNMMI Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg : Springer Berlin |
| مستخلص: | Background: Bone disease in multiple myeloma is characterized by reduced bone formation. The gold standard of bone formation is the mineral apposition rate (MAR), an invasive technique reflecting bone formation at a single site. We compared (18)F-fluoride-PET with the MAR in myeloma patients. Methods: Bone formation was measured before and after bortezomib treatment by determination of the MAR in iliac bone marrow biopsies and the measurement of (18)F-uptake. Results: The inter- and intra-individual variations in (18)F-uptake (SUVA50%) were pronounced as 33.50 (range 4.42 to 37.92) and 27.18 (range 4.00 to 31.18), respectively. A significant correlation between the MAR and (18)F-uptake was found (r = 0.80, p = 0.017). There was a heterogeneous response after treatment varying from -2.20 to 4.53. Conclusions: Iliac (18)F-uptake was associated with the local MAR in myeloma patients. Furthermore, (18)F-fluoride-PET demonstrated the heterogeneity of in vivo bone formation, enabling monitoring during treatment. |
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| تواريخ الأحداث: | Date Created: 20160602 Date Completed: 20160601 Latest Revision: 20200929 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4887457 |
| DOI: | 10.1186/s13550-016-0197-4 |
| PMID: | 27246327 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2191-219X |
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| DOI: | 10.1186/s13550-016-0197-4 |