دورية أكاديمية
Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer.
| العنوان: | Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer. |
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| المؤلفون: | Yamin G; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., Schenker-Ahmed NM; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., Shabaik A; Department of Pathology, University of California San Diego School of Medicine, San Diego, California., Adams D; Department of Pathology, University of California San Diego School of Medicine, San Diego, California., Bartsch H; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., Kuperman J; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., White NS; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., Rakow-Penner RA; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., McCammack K; Department of Radiology, University of California San Diego School of Medicine, San Diego, California., Parsons JK; Department of Surgery, University of California San Diego School of Medicine, San Diego, California., Kane CJ; Department of Surgery, University of California San Diego School of Medicine, San Diego, California., Dale AM; Department of Radiology, University of California San Diego School of Medicine, San Diego, California. Department of Neurosciences, University of California, San Diego, La Jolla, California., Karow DS; Department of Radiology, University of California San Diego School of Medicine, San Diego, California. dkarow@ucsd.edu. |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2016 Jun 01; Vol. 22 (11), pp. 2668-74. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging/*methods , Prostatic Neoplasms/*diagnostic imaging, Aged ; Data Interpretation, Statistical ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Neoplasm Grading ; Prostate ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Reproducibility of Results |
| مستخلص: | Purpose: Restriction spectrum imaging (RSI-MRI), an advanced diffusion imaging technique, can potentially circumvent current limitations in tumor conspicuity, in vivo characterization, and location demonstrated by multiparametric magnetic resonance imaging (MP-MRI) techniques in prostate cancer detection. Prior reports show that the quantitative signal derived from RSI-MRI, the cellularity index, is associated with aggressive prostate cancer as measured by Gleason grade (GG). We evaluated the reliability of RSI-MRI to predict variance with GG at the voxel-level within clinically demarcated prostate cancer regions. Experimental Design: Ten cases were processed using whole mount sectioning after radical prostatectomy. Regions of tumor were identified by an uropathologist. Stained prostate sections were scanned at high resolution (75 μm/pixel). A grid of tiles corresponding to voxel dimensions was graded using the GG system. RSI-MRI cellularity index was calculated from presurgical prostate MR scans and presented as normalized z-score maps. In total, 2,795 tiles were analyzed and compared with RSI-MRI cellularity. Results: RSI-MRI cellularity index was found to distinguish between prostate cancer and benign tumor (t = 25.48, P < 0.00001). Significant differences were also found between benign tissue and prostate cancer classified as low-grade (GG = 3; t = 11.56, P < 0.001) or high-grade (GG ≥ 4; t = 24.03, P < 0.001). Furthermore, RSI-MRI differentiated between low and high-grade prostate cancer (t = 3.23; P = 0.003). Conclusions: Building on our previous findings of correlation between GG and the RSI-MRI among whole tumors, our current study reveals a similar correlation at voxel resolution within tumors. Because it can detect variations in tumor grade with voxel-level precision, RSI-MRI may become an option for planning targeted procedures where identifying the area with the most aggressive disease is important. Clin Cancer Res; 22(11); 2668-74. ©2016 AACR. (©2016 American Association for Cancer Research.) |
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| معلومات مُعتمدة: | P30 NS047101 United States NS NINDS NIH HHS; T32 EB005970 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20160603 Date Completed: 20180122 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4896066 |
| DOI: | 10.1158/1078-0432.CCR-15-2429 |
| PMID: | 27250935 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-3265 |
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| DOI: | 10.1158/1078-0432.CCR-15-2429 |