دورية أكاديمية
Pretransplantation Donor-Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation.
| العنوان: | Pretransplantation Donor-Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation. |
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| المؤلفون: | Wunderink HF; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., van der Meijden E; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., van der Blij-de Brouwer CS; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Mallat MJ; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., Haasnoot GW; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., van Zwet EW; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands., Claas EC; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., Kroes AC; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Arnold F; UMR INRA 1282 ISP Université François Rabelais, Tours, France., Touzé A; UMR INRA 1282 ISP Université François Rabelais, Tours, France., Claas FH; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., Rotmans JI; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., Feltkamp MC; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands. |
| المصدر: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2017 Jan; Vol. 17 (1), pp. 161-172. Date of Electronic Publication: 2016 Jul 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Original Publication: Copenhagen : Munksgaard International Publishers, 2001- |
| مواضيع طبية MeSH: | BK Virus/*pathogenicity , Kidney Diseases/*diagnosis , Kidney Transplantation/*adverse effects , Polyomavirus Infections/*immunology , Tumor Virus Infections/*immunology , Viremia/*diagnosis, Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Kidney Diseases/etiology ; Kidney Function Tests ; Living Donors ; Male ; Middle Aged ; Netherlands/epidemiology ; Polyomavirus Infections/blood ; Polyomavirus Infections/virology ; Prognosis ; Retrospective Studies ; Risk Factors ; Transplant Recipients ; Tumor Virus Infections/blood ; Tumor Virus Infections/virology ; Viremia/etiology |
| مستخلص: | Kidney transplant donors are not currently implicated in predicting BK polyomavirus (BKPyV) infection in kidney transplant recipients. It has been postulated, however, that BKPyV infection originates from the kidney allograft. Because BKPyV seroreactivity correlates with BKPyV replication and thus might mirror the infectious load, we investigated whether BKPyV seroreactivity of the donor predicts viremia and BKPyV-associated nephropathy (BKPyVAN) in the recipient. In a retrospective cohort of 407 living kidney donor-recipient pairs, pretransplantation donor and recipient sera were tested for BKPyV IgG levels and correlated with the occurrence of recipient BKPyV viremia and BKPyVAN within 1 year after transplantation. Donor BKPyV IgG level was strongly associated with BKPyV viremia and BKPyVAN (p < 0.001), whereas recipient BKPyV seroreactivity showed a nonsignificant inverse trend. Pairing of high-BKPyV-seroreactive donors with low-seroreactive recipients resulted in a 10-fold increased risk of BKPyV viremia (hazard ratio 10.1, 95% CI 3.5-29.0, p < 0.001). In multivariate analysis, donor BKPyV seroreactivity was the strongest pretransplantation factor associated with viremia (p < 0.001) and BKPyVAN (p = 0.007). The proportional relationship between donor BKPyV seroreactivity and recipient infection suggests that donor BKPyV seroreactivity reflects the infectious load of the kidney allograft and calls for the use of pretransplantation BKPyV serological testing of (potential) donors and recipients. (© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.) |
| فهرسة مساهمة: | Keywords: BK polyomavirus; basic (laboratory) research/science; clinical research/practice; donors and donation: donor-derived infections; infection and infectious agents; infectious disease; kidney disease: infectious; kidney transplantation; kidney transplantation/nephrology; nephropathy; risk assessment/risk stratification; risk factors; serology; seroreactivity; viral: BK/JC/polyoma; viremia |
| تواريخ الأحداث: | Date Created: 20160603 Date Completed: 20171211 Latest Revision: 20230124 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/ajt.13880 |
| PMID: | 27251361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-6143 |
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| DOI: | 10.1111/ajt.13880 |