دورية أكاديمية
أعرض في EDS

P120-Catenin Regulates Early Trafficking Stages of the N-Cadherin Precursor Complex.

التفاصيل البيبلوغرافية
العنوان: P120-Catenin Regulates Early Trafficking Stages of the N-Cadherin Precursor Complex.
المؤلفون: Wehrendt DP; Instituto de Investigaciones Biotecnológicas, (IIB-INTECH), Universidad de San Martín, San Martín, Argentina., Carmona F; Instituto de Investigaciones Biotecnológicas, (IIB-INTECH), Universidad de San Martín, San Martín, Argentina., González Wusener AE; Instituto de Investigaciones Biotecnológicas, (IIB-INTECH), Universidad de San Martín, San Martín, Argentina., González Á; Instituto de Investigaciones Biotecnológicas, (IIB-INTECH), Universidad de San Martín, San Martín, Argentina., Martínez JM; Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, CABA, Argentina., Arregui CO; Instituto de Investigaciones Biotecnológicas, (IIB-INTECH), Universidad de San Martín, San Martín, Argentina.
المصدر: PloS one [PLoS One] 2016 Jun 02; Vol. 11 (6), pp. e0156758. Date of Electronic Publication: 2016 Jun 02 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cadherins/*metabolism , Catenins/*metabolism, Gene Knockdown Techniques ; HeLa Cells ; Humans ; Models, Biological ; N-Ethylmaleimide-Sensitive Proteins/metabolism ; Protein Binding ; Protein Processing, Post-Translational ; Protein Transport ; Secretory Pathway ; Delta Catenin
مستخلص: It is well established that binding of p120 catenin to the cytoplasmic domain of surface cadherin prevents cadherin endocytosis and degradation, contributing to cell-cell adhesion. In the present work we show that p120 catenin bound to the N-cadherin precursor, contributes to its anterograde movement from the endoplasmic reticulum (ER) to the Golgi complex. In HeLa cells, depletion of p120 expression, or blocking its binding to N-cadherin, increased the accumulation of the precursor in the ER, while it decreased the localization of mature N-cadherin at intercellular junctions. Reconstitution experiments in p120-deficient SW48 cells with all three major isoforms of p120 (1, 3 and 4) had similar capacity to promote the processing of the N-cadherin precursor to the mature form, and its localization at cell-cell junctions. P120 catenin and protein tyrosine phosphatase PTP1B facilitated the recruitment of the N-ethylmaleimide sensitive factor (NSF), an ATPase involved in vesicular trafficking, to the N-cadherin precursor complex. Dominant negative NSF E329Q impaired N-cadherin trafficking, maturation and localization at cell-cell junctions. Our results uncover a new role for p120 catenin bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.
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المشرفين على المادة: 0 (Cadherins)
0 (Catenins)
EC 3.6.4.6 (N-Ethylmaleimide-Sensitive Proteins)
0 (Delta Catenin)
0 (CTNND1 protein, human)
تواريخ الأحداث: Date Created: 20160603 Date Completed: 20170719 Latest Revision: 20221207
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4890775
DOI: 10.1371/journal.pone.0156758
PMID: 27254316
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0156758