دورية أكاديمية
أعرض في EDS

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.

التفاصيل البيبلوغرافية
العنوان: Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.
المؤلفون: Zhao Z; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Dammert MA; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Hoppe S; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Bierhoff H; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Grummt I; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany i.grummt@dkfz.de.
المصدر: Nucleic acids research [Nucleic Acids Res] 2016 Sep 30; Vol. 44 (17), pp. 8144-52. Date of Electronic Publication: 2016 Jun 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Heat-Shock Response/*genetics , Nucleosomes/*metabolism , Pol1 Transcription Initiation Complex Proteins/*metabolism , RNA, Long Noncoding/*metabolism , RNA, Ribosomal/*biosynthesis, Animals ; Casein Kinase II/metabolism ; Chromatin Assembly and Disassembly ; HEK293 Cells ; Histone-Lysine N-Methyltransferase ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; NIH 3T3 Cells ; Phosphorylation ; Promoter Regions, Genetic ; Transcription, Genetic
مستخلص: Attenuation of ribosome biogenesis in suboptimal growth environments is crucial for cellular homeostasis and genetic integrity. Here, we show that shutdown of rRNA synthesis in response to elevated temperature is brought about by mechanisms that target both the RNA polymerase I (Pol I) transcription machinery and the epigenetic signature of the rDNA promoter. Upon heat shock, the basal transcription factor TIF-IA is inactivated by inhibition of CK2-dependent phosphorylations at Ser170/172. Attenuation of pre-rRNA synthesis in response to heat stress is accompanied by upregulation of PAPAS, a long non-coding RNA (lncRNA) that is transcribed in antisense orientation to pre-rRNA. PAPAS interacts with CHD4, the adenosine triphosphatase subunit of NuRD, leading to deacetylation of histones and movement of the promoter-bound nucleosome into a position that is refractory to transcription initiation. The results exemplify how stress-induced inactivation of TIF-IA and lncRNA-dependent changes of chromatin structure ensure repression of rRNA synthesis in response to thermo-stress.
(© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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المشرفين على المادة: 0 (Nucleosomes)
0 (Pol1 Transcription Initiation Complex Proteins)
0 (RNA, Long Noncoding)
0 (RNA, Ribosomal)
0 (Rrn3 protein, mouse)
0 (long non-coding RNA PAPAS, mouse)
EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
EC 2.7.11.1 (Casein Kinase II)
EC 3.5.1.98 (Mi-2 Nucleosome Remodeling and Deacetylase Complex)
تواريخ الأحداث: Date Created: 20160604 Date Completed: 20170613 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5041454
DOI: 10.1093/nar/gkw496
PMID: 27257073
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkw496