دورية أكاديمية
Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy.
| العنوان: | Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy. |
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| المؤلفون: | Alvarado-Hernández DL; Laboratorio de Genómica Viral y Humana, Facultad de Medicina UASLP, San Luis Potosí, México., Benítez-Sánchez A; División de Gineco-Obstetricia, Hospital Central 'Dr. Ignacio Morones Prieto', San Luis Potosí, México., Rodríguez-Cuevas JS; División de Gineco-Obstetricia, Hospital Central 'Dr. Ignacio Morones Prieto', San Luis Potosí, México., Rosales-Saavedra T; Laboratorio de Genómica Viral y Humana, Facultad de Medicina UASLP, San Luis Potosí, México., Guerra-Palomares SE; Laboratorio de Genómica Viral y Humana, Facultad de Medicina UASLP, San Luis Potosí, México., Comas-García A; Departamento de Microbiología, Facultad de Medicina UASLP, San Luis Potosí, México., Noyola DE; Departamento de Microbiología, Facultad de Medicina UASLP, San Luis Potosí, México., García-Sepúlveda CA; Laboratorio de Genómica Viral y Humana, Facultad de Medicina UASLP, San Luis Potosí, México. |
| المصدر: | International journal of immunogenetics [Int J Immunogenet] 2016 Aug; Vol. 43 (4), pp. 189-99. Date of Electronic Publication: 2016 Jun 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Pub., c2005- |
| مواضيع طبية MeSH: | Cytomegalovirus Infections/*genetics , Immunity, Innate/*genetics , Receptors, KIR/*genetics , Receptors, KIR2DL5/*genetics, Adolescent ; Adult ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Female ; Genetic Association Studies ; Genotype ; HLA-C Antigens/genetics ; HLA-C Antigens/immunology ; Haplotypes ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Killer Cells, Natural/immunology ; Pregnancy ; Receptors, KIR/immunology ; Receptors, KIR2DL5/immunology |
| مستخلص: | Human cytomegalovirus (CMV) represents an important public health concern as it is associated with severe morbidity and mortality in transplant recipients, HIV-infected individuals and pregnant women given the risk of congenital infection. Congenital CMV is a leading cause of neurological sequelae, developmental delay and birth defects worldwide. Cytomegalovirus can be transmitted to the foetus following maternal infection or reactivation. NK cells expressing killer-cell immunoglobulin-like receptors (KIR) are part of the innate immune system and the first line of defence against viral incursions. Previous reports have shown that KIR genes are associated with CMV infections in the post-transplant setting. In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer-cell immunoglobulin-like receptors and HLA-C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR-SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene pair and of KIR2DL5 amongst CMV-positive pregnant women in comparison with those CMV negative. None of these were associated with CMV status in the reference population. Logistic regression analysis revealed that the most important factor determining CMV status during third-trimester pregnancies was the KIR2DL5 + 2DS3/2DS5 gene pair (OR 0.376 (95%CI 0.174, 0.811, P = 0.013). Our results indicate that CMV-protective KIR gene associations described in Caucasoid populations are also present in the genetically distinct Mexican mestizo population. Our results suggest that certain KIR gene combinations provide protection against CMV infections occurring during late-term pregnancies, a finding of utmost epidemiological importance given its implication with congenital CMV infections. (© 2016 John Wiley & Sons Ltd.) |
| المشرفين على المادة: | 0 (HLA-C Antigens) 0 (KIR2DS3 protein, human) 0 (Receptors, KIR) 0 (Receptors, KIR2DL5) |
| تواريخ الأحداث: | Date Created: 20160610 Date Completed: 20170317 Latest Revision: 20170317 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/iji.12271 |
| PMID: | 27277336 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1744-313X |
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| DOI: | 10.1111/iji.12271 |