دورية أكاديمية
أعرض في EDS

Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France.

التفاصيل البيبلوغرافية
العنوان: Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France.
المؤلفون: de Rougemont A; Centre National de Référence des virus entériques, Laboratoire de Virologie, CHU de Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France. Electronic address: alexis.de-rougemont@u-bourgogne.fr., Kaplon J; Centre National de Référence des virus entériques, Laboratoire de Virologie, CHU de Dijon, France., Fremy C; Centre National de Référence des virus entériques, Laboratoire de Virologie, CHU de Dijon, France., Legrand-Guillien MC; Centre Hospitalier Universitaire de Brest, France., Minoui-Tran A; Centre Hospitalier Universitaire de Brest, France., Payan C; Centre Hospitalier Universitaire de Brest, France., Vabret A; Centre Hospitalier Universitaire de Caen, France., Mendes-Martins L; Centre Hospitalier de Charleville-Mézières, France., Chouchane M; Centre Hospitalier Universitaire de Dijon, France., Maudinas R; Centre Hospitalier Universitaire de Dijon, France., Huet F; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France; Centre Hospitalier Universitaire de Dijon, France., Dubos F; Centre Hospitalier Régional Universitaire de Lille, France., Hober D; Centre Hospitalier Régional Universitaire de Lille, France., Lazrek M; Centre Hospitalier Régional Universitaire de Lille, France., Bouquignaud C; Groupement des Hôpitaux de l'Institut Catholique de Lille, France., Decoster A; Groupement des Hôpitaux de l'Institut Catholique de Lille, France., Alain S; Centre Hospitalier Universitaire de Limoges, France., Languepin J; Centre Hospitalier Universitaire de Limoges, France., Gillet Y; Hospices Civils de Lyon, France., Lina B; Hospices Civils de Lyon, France., Mekki Y; Hospices Civils de Lyon, France., Morfin-Sherpa F; Hospices Civils de Lyon, France., Guigon A; Centre Hospitalier Universitaire d'Orléans, France., Guinard J; Centre Hospitalier Universitaire d'Orléans, France., Foulongne V; Centre Hospitalier Universitaire de Montpellier, France., Rodiere M; Centre Hospitalier Universitaire de Montpellier, France., Avettand-Fenoel V; Assistance Publique Hôpitaux de Paris, France., Bonacorsi S; Assistance Publique Hôpitaux de Paris, France., Garbarg-Chenon A; Assistance Publique Hôpitaux de Paris, France., Gendrel D; Assistance Publique Hôpitaux de Paris, France., Lebon P; Assistance Publique Hôpitaux de Paris, France., Lorrot M; Assistance Publique Hôpitaux de Paris, France., Mariani P; Assistance Publique Hôpitaux de Paris, France., Meritet JF; Assistance Publique Hôpitaux de Paris, France., Schnuriger A; Assistance Publique Hôpitaux de Paris, France., Agius G; Centre Hospitalier Universitaire de Poitiers, France., Beby-Defaux A; Centre Hospitalier Universitaire de Poitiers, France., Oriot D; Centre Hospitalier Universitaire de Poitiers, France., Colimon R; Centre Hospitalier Universitaire de Rennes, France., Lagathu G; Centre Hospitalier Universitaire de Rennes, France., Mory O; Centre Hospitalier Universitaire de Saint-Etienne, France., Pillet S; Centre Hospitalier Universitaire de Saint-Etienne, France., Pozzetto B; Centre Hospitalier Universitaire de Saint-Etienne, France., Stephan JL; Centre Hospitalier Universitaire de Saint-Etienne, France., Aho S; Service d'Hygiène Hospitalière, Centre Hospitalier Universitaire de Dijon, France., Pothier P; Centre National de Référence des virus entériques, Laboratoire de Virologie, CHU de Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France.
مؤلفون مشاركون: French National Rotavirus Network
المصدر: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2016 Aug; Vol. 22 (8), pp. 737.e9-737.e15. Date of Electronic Publication: 2016 Jun 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : London : Elsevier
Original Publication: Paris : Decker Europe, c1995-
مواضيع طبية MeSH: Communicable Diseases, Emerging* , Emergency Service, Hospital*, Rotavirus/*genetics , Rotavirus Infections/*epidemiology , Rotavirus Infections/*virology, Animals ; Child, Preschool ; Feces/virology ; Female ; France/epidemiology ; Genotype ; Humans ; Infant ; Infant, Newborn ; Male ; Phylogeny ; Prevalence ; Reassortant Viruses ; Rotavirus/classification ; Rotavirus/isolation & purification ; Rotavirus Infections/diagnosis ; Seasons ; Severity of Illness Index
مستخلص: Group A rotavirus (RVA) is the leading cause of acute gastroenteritis in young children worldwide. A prospective surveillance network has been set up to investigate the virological and clinical features of RVA infections and to detect the emergence of potentially epidemic strains in France. From 2009 to 2014, RVA-positive stool samples were collected from 4800 children <5 years old attending the paediatric emergency units of 16 large hospitals. Rotaviruses were then genotyped by RT-PCR with regard to their outer capsid proteins VP4 and VP7. Genotyping of 4708 RVA showed that G1P[8] strains (62.2%) were predominant. The incidence of G9P[8] (11.5%), G3P[8] (10.4%) and G2P[4] (6.6%) strains varied considerably, whereas G4P[8] (2.7%) strains were circulating mostly locally. Of note, G12P[8] (1.6%) strains emerged during the seasons 2011-12 and 2012-13 with 4.1% and 3.0% prevalence, respectively. Overall, 40 possible zoonotic reassortants, such as G6 (33.3%) and G8 (15.4%) strains, were detected, and were mostly associated with P[6] (67.5%). Analysis of clinical records of 624 hospitalized children and severity scores from 282 of them showed no difference in clinical manifestations or severity in relation to the genotype. The relative stability of RVA genotypes currently co-circulating and the large predominance of P[8] type strains may ensure vaccine effectiveness in France. The surveillance will continue to monitor the emergence of new reassortants that might not respond to current vaccines, all the more so as all genotypes can cause severe infections in infants.
(Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Acute gastroenteritis; Diarrhoea; Emerging rotavirus; Genotyping; Rotavirus; Severity
تواريخ الأحداث: Date Created: 20160612 Date Completed: 20170206 Latest Revision: 20170206
رمز التحديث: 20240628
DOI: 10.1016/j.cmi.2016.05.025
PMID: 27287887
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-0691
DOI:10.1016/j.cmi.2016.05.025