دورية أكاديمية
أعرض في EDS

Long-term in vivo polychlorinated biphenyl 126 exposure induces oxidative stress and alters proteomic profile on islets of Langerhans.

التفاصيل البيبلوغرافية
العنوان: Long-term in vivo polychlorinated biphenyl 126 exposure induces oxidative stress and alters proteomic profile on islets of Langerhans.
المؤلفون: Loiola RA; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Dos Anjos FM; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Shimada AL; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Cruz WS; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Drewes CC; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Rodrigues SF; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Cardozo KH; Fleury Group, São Paulo, Brazil., Carvalho VM; Fleury Group, São Paulo, Brazil., Pinto E; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Farsky SH; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
المصدر: Scientific reports [Sci Rep] 2016 Jun 13; Vol. 6, pp. 27882. Date of Electronic Publication: 2016 Jun 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Islets of Langerhans/*drug effects , Oxidative Stress/*drug effects , Polychlorinated Biphenyls/*toxicity , Proteome/*drug effects, Adipose Tissue/metabolism ; Administration, Intranasal ; Animals ; Body Weight/drug effects ; Cell Survival/drug effects ; Cholesterol/blood ; Glucose/metabolism ; Insulin/blood ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Kidney/drug effects ; Kidney/metabolism ; Lipid Metabolism/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Nitric Oxide/metabolism ; Rats ; Rats, Wistar ; Triglycerides/blood ; Up-Regulation/drug effects
مستخلص: It has been recently proposed that exposure to polychlorinated biphenyls (PCBs) is a risk factor to type 2 diabetes mellitus (DM2). We investigated this hypothesis using long-term in vivo PCB126 exposure to rats addressing metabolic, cellular and proteomic parameters. Male Wistar rats were exposed to PCB126 (0.1, 1 or 10 μg/kg of body weight/day; for 15 days) or vehicle by intranasal instillation. Systemic alterations were quantified by body weight, insulin and glucose tolerance, and blood biochemical profile. Pancreatic toxicity was measured by inflammatory parameters, cell viability and cycle, free radical generation, and proteomic profile on islets of Langerhans. In vivo PCB126 exposure enhanced the body weight gain, impaired insulin sensitivity, reduced adipose tissue deposit, and elevated serum triglycerides, cholesterol, and insulin levels. Inflammatory parameters in the pancreas and cell morphology, viability and cycle were not altered in islets of Langerhans. Nevertheless, in vivo PCB126 exposure increased free radical generation and modified the expression of proteins related to oxidative stress on islets of Langerhans, which are indicative of early β-cell failure. Data herein obtained show that long-term in vivo PCB126 exposure through intranasal route induced alterations on islets of Langerhans related to early end points of DM2.
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المشرفين على المادة: 0 (Insulin)
0 (Proteome)
0 (Triglycerides)
31C4KY9ESH (Nitric Oxide)
97C5T2UQ7J (Cholesterol)
DFC2HB4I0K (Polychlorinated Biphenyls)
IY9XDZ35W2 (Glucose)
TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
تواريخ الأحداث: Date Created: 20160614 Date Completed: 20180515 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4904407
DOI: 10.1038/srep27882
PMID: 27292372
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep27882