دورية أكاديمية
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fMRI mapping of the visual system in the mouse brain with interleaved snapshot GE-EPI.

التفاصيل البيبلوغرافية
العنوان: fMRI mapping of the visual system in the mouse brain with interleaved snapshot GE-EPI.
المؤلفون: Niranjan A; UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, UK., Christie IN; UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, UK; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK., Solomon SG; Department of Experimental Psychology, University College London, London, UK., Wells JA; UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, UK., Lythgoe MF; UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, UK.
المصدر: NeuroImage [Neuroimage] 2016 Oct 01; Vol. 139, pp. 337-345. Date of Electronic Publication: 2016 Jun 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1992-
مواضيع طبية MeSH: Brain/*physiology , Brain Mapping/*methods , Visual Pathways/*physiology , Visual Perception/*physiology, Animals ; Female ; Geniculate Bodies/physiology ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Mice, Inbred C57BL ; Photic Stimulation ; Signal Processing, Computer-Assisted ; Superior Colliculi/physiology ; Visual Cortex/physiology
مستخلص: The use of functional magnetic resonance imaging (fMRI) in mice is increasingly prevalent, providing a means to non-invasively characterise functional abnormalities associated with genetic models of human diseases. The predominant stimulus used in task-based fMRI in the mouse is electrical stimulation of the paw. Task-based fMRI in mice using visual stimuli remains underexplored, despite visual stimuli being common in human fMRI studies. In this study, we map the mouse brain visual system with BOLD measurements at 9.4T using flashing light stimuli with medetomidine anaesthesia. BOLD responses were observed in the lateral geniculate nucleus, the superior colliculus and the primary visual area of the cortex, and were modulated by the flashing frequency, diffuse vs focussed light and stimulus context. Negative BOLD responses were measured in the visual cortex at 10Hz flashing frequency; but turned positive below 5Hz. In addition, the use of interleaved snapshot GE-EPI improved fMRI image quality without diminishing the temporal contrast-noise-ratio. Taken together, this work demonstrates a novel methodological protocol in which the mouse brain visual system can be non-invasively investigated using BOLD fMRI.
(Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: MR/J013110/1 United Kingdom MRC_ Medical Research Council; MR/K026739/1 United Kingdom MRC_ Medical Research Council; NC/L000385/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research
فهرسة مساهمة: Keywords: Mouse; Negative BOLD; Visual cortex; fMRI
تواريخ الأحداث: Date Created: 20160615 Date Completed: 20180208 Latest Revision: 20231115
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4988789
DOI: 10.1016/j.neuroimage.2016.06.015
PMID: 27296012
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9572
DOI:10.1016/j.neuroimage.2016.06.015