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Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats.

التفاصيل البيبلوغرافية
العنوان: Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats.
المؤلفون: Pinto IS; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Mourão AA; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., da Silva EF; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Camargo AS; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Marques SM; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Gomes KP; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Fajemiroye JO; Postgraduate Programme in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Goiás Goiânia, Brazil., da Silva Reis AA; Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Rebelo AC; Department of Morphology, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Ferreira-Neto ML; Department of Physiology, College of Physical Education, Federal University of Uberlândia Uberlândia, Brazil., Rosa DA; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Freiria-Oliveira AH; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Castro CH; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Colombari E; Department of Physiology and Pathology, School of Dentistry, São Paulo State University Araraquara, Brazil., Colugnati DB; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil., Pedrino GR; Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2016 Jun 02; Vol. 7, pp. 205. Date of Electronic Publication: 2016 Jun 02 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Intrathecal injection of bombesin (BBS) promoted hypertensive and sympathoexcitatory effects in normotensive (NT) rats. However, the involvement of rostral ventrolateral medulla (RVLM) in these responses is still unclear. In the present study, we investigated: (1) the effects of BBS injected bilaterally into RVLM on cardiorespiratory and sympathetic activity in NT and spontaneously hypertensive rats (SHR); (2) the contribution of RVLM BBS type 1 receptors (BB1) to the maintenance of hypertension in SHR. Urethane-anesthetized rats (1.2 g · kg(-1), i.v.) were instrumented to record mean arterial pressure (MAP), diaphragm (DIA) motor, and renal sympathetic nerve activity (RSNA). In NT rats and SHR, BBS (0.3 mM) nanoinjected into RVLM increased MAP (33.9 ± 6.6 and 37.1 ± 4.5 mmHg, respectively; p < 0.05) and RSNA (97.8 ± 12.9 and 84.5 ± 18.1%, respectively; p < 0.05). In SHR, BBS also increased DIA burst amplitude (115.3 ± 22.7%; p < 0.05). BB1 receptors antagonist (BIM-23127; 3 mM) reduced MAP (-19.9 ± 4.4 mmHg; p < 0.05) and RSNA (-17.7 ± 3.8%; p < 0.05) in SHR, but not in NT rats (-2.5 ± 2.8 mmHg; -2.7 ± 5.6%, respectively). These results show that BBS can evoke sympathoexcitatory and pressor responses by activating RVLM BB1 receptors. This pathway might be involved in the maintenance of high levels of arterial blood pressure in SHR.
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فهرسة مساهمة: Keywords: BB1 receptors; BIM-23127; SHR; bombesin; rostral ventrolateral medulla
تواريخ الأحداث: Date Created: 20160618 Date Completed: 20160617 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC4889888
DOI: 10.3389/fphys.2016.00205
PMID: 27313544
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2016.00205