دورية أكاديمية

Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration.

التفاصيل البيبلوغرافية
العنوان: Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration.
المؤلفون: Go BS; Department of Biological Sciences, Pusan National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Busan, 46241, Korea.; Department of Psychology, Washington State University, 100 Dairy Road, Pullman, WA, 99164, USA., Kim J; Department of Biological Sciences, Pusan National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Busan, 46241, Korea., Yang JH; Department of Biological Sciences, Pusan National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Busan, 46241, Korea., Choe ES; Department of Biological Sciences, Pusan National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Busan, 46241, Korea. eschoe@pusan.ac.kr.
المصدر: Molecular neurobiology [Mol Neurobiol] 2017 Aug; Vol. 54 (6), pp. 4041-4048. Date of Electronic Publication: 2016 Jun 17.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH: Central Nervous System Stimulants/*adverse effects , Endoplasmic Reticulum Stress/*drug effects , Nerve Degeneration/*chemically induced , Nerve Degeneration/*pathology, Animals ; Caspases/metabolism ; Humans ; Nitric Oxide/metabolism ; Oxidative Stress
مستخلص: The endoplasmic reticulum (ER) is a subcellular organelle that ensures proper protein folding process. The ER stress is defined as cellular conditions that disturb the ER homeostasis, resulting in accumulation of unfolded and/or misfolded proteins in the lumen of the ER. The presence of these proteins within the ER activates the ER stress response, known as unfolded protein response (UPR), to restore normal functions of the ER. However, under the severe and/or prolonged ER stress, UPR initiates apoptotic cell death. Psychostimulants such as cocaine, amphetamine, and methamphetamine cause the ER stress and/or apoptotic cell death in regions of the brain related to drug addiction. Recent studies have shown that the ER stress in response to psychostimulants is linked to behavioral sensitization and that the psychostimulant-induced ER stress signaling cascades are closely associated with the pathogenesis of the neurodegenerative diseases. Therefore, this review was conducted to improve understanding of the functional role of the ER stress in the addiction as well as neurodegenerative diseases. This would be helpful to facilitate development of new therapeutic strategies for the drug addiction and/or neurodegenerative diseases caused or exacerbated by exposure to psychostimulants.
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فهرسة مساهمة: Keywords: Caspase; Drugs of abuse; JNK; Neurodegenerative disease; Oxidative stress
المشرفين على المادة: 0 (Central Nervous System Stimulants)
31C4KY9ESH (Nitric Oxide)
EC 3.4.22.- (Caspases)
تواريخ الأحداث: Date Created: 20160618 Date Completed: 20180409 Latest Revision: 20181113
رمز التحديث: 20231215
DOI: 10.1007/s12035-016-9969-0
PMID: 27314686
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1182
DOI:10.1007/s12035-016-9969-0