دورية أكاديمية
أعرض في EDS

Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study.

التفاصيل البيبلوغرافية
العنوان: Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study.
المؤلفون: Erichsen R; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark. Electronic address: re@clin.au.dk., Kelsh MA; Center for Observational Research, Amgen Inc., Thousand Oaks, CA., Oliner KS; Medical Sciences, Amgen Inc., Thousand Oaks, CA., Nielsen KB; Dako Denmark A/S, Glostrup, Denmark., Frøslev T; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark., Lænkholm AV; Department of Pathology, Slagelse Hospital, Slagelse, Denmark., Vyberg M; Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark., Acquavella J; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark; Center for Observational Research, Amgen Inc., Thousand Oaks, CA., Sørensen HT; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
المصدر: Annals of epidemiology [Ann Epidemiol] 2016 Jul; Vol. 26 (7), pp. 500-503. Date of Electronic Publication: 2016 May 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9100013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2585 (Electronic) Linking ISSN: 10472797 NLM ISO Abbreviation: Ann Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier, c1990-
مواضيع طبية MeSH: Adenocarcinoma/*metabolism , Adenocarcinoma/*mortality , Biomarkers, Tumor/*metabolism , Proto-Oncogene Proteins c-met/*metabolism , Stomach Neoplasms/*metabolism , Stomach Neoplasms/*mortality, Adenocarcinoma/pathology ; Adult ; Aged ; Cohort Studies ; Confidence Intervals ; Databases, Factual ; Denmark ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Mas ; Retrospective Studies ; Risk Assessment ; Stomach Neoplasms/pathology ; Survival Analysis
مستخلص: Purpose: We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse.
Methods: The study included archived cancer specimens from 103 stage IV gastric cancer patients (2003-2010). We analyzed MET-protein expression by immunohistochemistry (MET-positive if ≥25% of tumor cells showed MET expression). We calculated overall survival using the Kaplan-Meier method and hazard ratios comparing mortality among MET-positive and MET-negative patients using Cox regression adjusted for age, gender, and comorbidity.
Results: We found that 62.1% (95% confidence interval, 52.0-71.5) of patients had MET-positive tumors. Median survival was lower among patients with MET-positive tumors (3.5 months) than among patients with MET-negative tumors (9.6 months), corresponding to an adjusted hazard ratio of 2.2 (95% confidence interval, 1.3-3.7).
Conclusions: Tumor MET expression is prevalent and has substantial prognostic impact in stage IV gastric cancer patients.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Cohort studies; Mortality; Prevalence; Proto-oncogene proteins c-met; Stomach neoplasia
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (MAS1 protein, human)
0 (Proto-Oncogene Mas)
EC 2.7.10.1 (MET protein, human)
EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
تواريخ الأحداث: Date Created: 20160620 Date Completed: 20180126 Latest Revision: 20220311
رمز التحديث: 20221213
DOI: 10.1016/j.annepidem.2016.05.002
PMID: 27318530
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2585
DOI:10.1016/j.annepidem.2016.05.002