دورية أكاديمية
أعرض في EDS

Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice.

التفاصيل البيبلوغرافية
العنوان: Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice.
المؤلفون: Eraky MA; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt. maysa.hassan@fmed.bu.edu.eg., El-Kholy AA; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Rashed GA; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Hammam OA; Department of Pathology, Theodore Bilharz Research Institute, Giza, Egypt., Moharam AF; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Abou-Ouf EA; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Aly NS; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Kishik SM; Department of Parasitology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Abdallah KF; Medical Parasitology Department, College of Medicine, Taif University, Taif, Saudi Arabia., Hamdan DI; Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
المصدر: Parasitology research [Parasitol Res] 2016 Oct; Vol. 115 (10), pp. 4045-54. Date of Electronic Publication: 2016 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Limonins/*administration & dosage , Praziquantel/*administration & dosage , Schistosoma mansoni/*drug effects , Schistosomiasis mansoni/*drug therapy , Schistosomicides/*administration & dosage, Administration, Oral ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Resistance ; Female ; Granuloma/parasitology ; Granuloma/pathology ; Intestines/parasitology ; Intestines/pathology ; Liver/parasitology ; Liver/pathology ; Male ; Mice ; Parasite Egg Count ; Schistosomiasis mansoni/parasitology
مستخلص: Preventive chemotherapy with praziquantel is the mainstay of schistosomiasis control. However, drug resistance is an imminent threat, particularly with large-scale administration of praziquantel, in addition to much less efficacy against young schistosomes. Several biological activities of limonin have been explored such as insecticidal, insect antifeedant, and growth-regulating activity on insects as well as antimalarial, antiviral, anticancer, cholesterol-lowering, and antioxidant activities. This study investigates limonin as an alternative antischistosomal compound using two novel, single, oral dose regimens. In the current work, the therapeutic efficacy of different limonin dosing protocols was evaluated in experimentally infected mice harboring Schistosoma mansoni (Egyptian strain) juvenile or adult stages. Oral administration of limonin in a single dose of 50 or 100 mg/kg on day 21 post-infection (p.i.) resulted in a significant worm burden reduction of 70.0 and 83.33 %, respectively. The same dose given on day 56 p.i. reduced total worm burdens by 41.09 and 60.27 %, respectively. In addition, significant reductions of 34.90 and 47.16 % in the hepatic and 46.67 and 56.1 % in the intestinal tissue egg loads, respectively, associated with significant alterations in the oogram pattern with elevated dead egg levels. Limonin produced ameliorations of hepatic pathology with reduction in dimensions and number of granulomas. Limonin also produced a variety of tegumental alterations in treated worms including tubercular disruption, edema, blebbing, and ulcerations. Results obtained by this work elucidated promising limonin bioactivity against S. mansoni juvenile and adult stages and provided a basis for subsequent experimental and clinical trials.
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فهرسة مساهمة: Keywords: Adult; In vivo; Juvenile; Limonin; Natural plants; S. mansoni
المشرفين على المادة: 0 (Limonins)
0 (Schistosomicides)
6490C9U457 (Praziquantel)
L0F260866S (limonin)
تواريخ الأحداث: Date Created: 20160622 Date Completed: 20170502 Latest Revision: 20181202
رمز التحديث: 20240628
DOI: 10.1007/s00436-016-5177-0
PMID: 27325399
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1955
DOI:10.1007/s00436-016-5177-0