دورية أكاديمية
Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses.
| العنوان: | Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses. |
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| المؤلفون: | Natesan M; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA mohan.natesan.ctr@mail.mil robert.g.ulrich.civ@mail.mil., Jensen SM; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Keasey SL; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Kamata T; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Stonier SW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Lutwama JJ; Department of Arbovirology, Emerging and Re-emerging Infection, Uganda Virus Research Institute, Entebbe, Uganda., Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Ulrich RG; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA mohan.natesan.ctr@mail.mil robert.g.ulrich.civ@mail.mil. |
| المصدر: | Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2016 Aug 05; Vol. 23 (8), pp. 717-24. Date of Electronic Publication: 2016 Aug 05 (Print Publication: 2016). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101252125 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1556-679X (Electronic) Linking ISSN: 1556679X NLM ISO Abbreviation: Clin Vaccine Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Society for Microbiology, [2006]- |
| مواضيع طبية MeSH: | Cross Reactions*, Antibodies, Viral/*blood , Ebolavirus/*immunology , Hemorrhagic Fever, Ebola/*immunology , Marburg Virus Disease/*immunology , Marburgvirus/*immunology, Animals ; Antibody Formation ; Antigens, Viral/immunology ; Cohort Studies ; Disease Outbreaks ; Healthy Volunteers ; Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Marburg Virus Disease/epidemiology ; Microarray Analysis ; Protein Array Analysis ; Survivors ; Viral Structural Proteins/genetics |
| مستخلص: | A detailed understanding of serological immune responses to Ebola and Marburg virus infections will facilitate the development of effective diagnostic methods, therapeutics, and vaccines. We examined antibodies from Ebola or Marburg survivors 1 to 14 years after recovery from disease, by using a microarray that displayed recombinant nucleoprotein (NP), viral protein 40 (VP40), envelope glycoprotein (GP), and inactivated whole virions from six species of filoviruses. All three outbreak cohorts exhibited significant antibody responses to antigens from the original infecting species and a pattern of additional filoviruses that varied by outbreak. NP was the most cross-reactive antigen, while GP was the most specific. Antibodies from survivors of infections by Marburg marburgvirus (MARV) species were least cross-reactive, while those from survivors of infections by Sudan virus (SUDV) species exhibited the highest cross-reactivity. Based on results revealed by the protein microarray, persistent levels of antibodies to GP, NP, and VP40 were maintained for up to 14 years after infection, and survival of infection caused by one species imparted cross-reactive antibody responses to other filoviruses. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.) |
| References: | Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4275-80. (PMID: 22371572) Mol Biol Evol. 2000 Apr;17(4):540-52. (PMID: 10742046) Virus Res. 2013 Sep;176(1-2):83-90. (PMID: 23702199) N Engl J Med. 2015 Jun 18;372(25):2467-9. (PMID: 26083224) Lancet. 1991 Feb 16;337(8738):425-6. (PMID: 1671441) J Mol Biol. 2000 Sep 8;302(1):205-17. (PMID: 10964570) Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17123-7. (PMID: 17942693) Lancet. 2000 Jun 24;355(9222):2210-5. (PMID: 10881895) N Engl J Med. 2013 Aug 1;369(5):492-3. (PMID: 23902512) Emerg Infect Dis. 2003 Nov;9(11):1430-7. (PMID: 14718087) Bioinformatics. 2006 Jan 1;22(1):117-9. (PMID: 16234319) PLoS One. 2010 Feb 09;5(2):e9126. (PMID: 20161740) Nat Med. 1999 Apr;5(4):423-6. (PMID: 10202932) J Virol. 1998 Aug;72(8):6442-7. (PMID: 9658086) Nucleic Acids Res. 2011 Jul;39(Web Server issue):W13-7. (PMID: 21558174) Lancet Infect Dis. 2016 Jan;16(1):31-42. (PMID: 26546548) J Virol. 2005 Jan;79(2):918-26. (PMID: 15613320) Emerg Infect Dis. 2009 Jul;15(7):1136-7. (PMID: 19624943) Emerg Infect Dis. 2014 Oct;20(10):1683-90. (PMID: 25279581) J Virol. 2007 Feb;81(4):1821-37. (PMID: 17151111) J Infect Dis. 2011 Nov;204 Suppl 3:S897-903. (PMID: 21987767) J Infect Dis. 1999 Feb;179 Suppl 1:S192-8. (PMID: 9988184) Clin Exp Immunol. 2001 Jun;124(3):453-60. (PMID: 11472407) Science. 2009 Jul 10;325(5937):204-6. (PMID: 19590002) Virology. 2015 May;479-480:532-44. (PMID: 25824479) N Engl J Med. 2016 Jan 7;374(1):33-42. (PMID: 26735992) Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3602-7. (PMID: 8622982) N Engl J Med. 2014 Dec 18;371(25):2402-9. (PMID: 25390460) J Virol. 2007 Dec;81(24):13378-84. (PMID: 17928356) PLoS One. 2007 Aug 22;2(8):e764. (PMID: 17712412) J Infect Dis. 2015 Oct 1;212 Suppl 2:S101-8. (PMID: 25786916) Lancet Infect Dis. 2015 Sep;15(9):991-2. (PMID: 26201297) J Infect Dis. 2013 Jul 15;208(2):299-309. (PMID: 23585686) J Infect Dis. 1999 Feb;179 Suppl 1:S87-91. (PMID: 9988169) Nature. 2015 Aug 6;524(7563):102-4. (PMID: 26106863) Clin Vaccine Immunol. 2014 Dec;21(12):1605-12. (PMID: 25230936) Virus Res. 2016 Jan 4;211:174-85. (PMID: 26596227) Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4719-24. (PMID: 25775592) J Clin Microbiol. 2001 Jan;39(1):1-7. (PMID: 11136739) PLoS Negl Trop Dis. 2011 Jun;5(6):e1175. (PMID: 21666792) Virology. 1991 May;182(1):353-6. (PMID: 2024471) Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1893-8. (PMID: 23319647) EMBO J. 2000 Aug 15;19(16):4228-36. (PMID: 10944105) Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21. (PMID: 11309499) Vector Borne Zoonotic Dis. 2009 Dec;9(6):723-8. (PMID: 19323614) Syst Biol. 2007 Aug;56(4):564-77. (PMID: 17654362) Viruses. 2015 Jan 06;7(1):37-51. (PMID: 25569078) Syst Biol. 2010 May;59(3):307-21. (PMID: 20525638) Bioinformatics. 2007 Nov 1;23(21):2947-8. (PMID: 17846036) Clin Infect Dis. 2016 Jan 1;62(1):69-74. (PMID: 26261205) Virol J. 2012 Oct 13;9:236. (PMID: 23062147) Genome Res. 1998 Dec;8(12):1233-44. (PMID: 9872979) |
| معلومات مُعتمدة: | R01 AI096215 United States AI NIAID NIH HHS; U19 AI109762 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antigens, Viral) 0 (Viral Structural Proteins) |
| تواريخ الأحداث: | Date Created: 20160624 Date Completed: 20170414 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4979172 |
| DOI: | 10.1128/CVI.00107-16 |
| PMID: | 27335383 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1556-679X |
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| DOI: | 10.1128/CVI.00107-16 |