دورية أكاديمية
أعرض في EDS

Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients.

التفاصيل البيبلوغرافية
العنوان: Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients.
المؤلفون: Teltschik HM; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Heinzelmann F; Department of Radiation Oncology, UH of Tuebingen, Tuebingen, Germany., Gruhn B; Children's University Hospital, UH of Jena, Jena, Germany., Feuchtinger T; Dr. von Hauner'sches Kinderspital, Ludwig-Maximilians-Universität Munich, Munich, Germany., Schlegel P; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Schumm M; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Kremens B; Children's University Hospital, UH of Essen, Essen, Germany., Müller I; Clinic for Paediatric Haematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Ebinger M; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Schwarze CP; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Ottinger H; Department of Bone Marrow Transplantation, UH of Essen, Essen, Germany., Zips D; Department of Radiation Oncology, UH of Tuebingen, Tuebingen, Germany., Handgretinger R; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany., Lang P; Children's University Hospital, University Hospital (UH) of Tuebingen, Tuebingen, Germany. peter.lang@med.uni-tuebingen.de.
المصدر: British journal of haematology [Br J Haematol] 2016 Oct; Vol. 175 (1), pp. 115-22. Date of Electronic Publication: 2016 Jun 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Haplotypes* , Hematopoietic Stem Cell Transplantation*/adverse effects , Hematopoietic Stem Cell Transplantation*/methods , Transplantation Conditioning*/methods, Graft Rejection/*therapy , HLA Antigens/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Graft Rejection/mortality ; Graft Survival ; Graft vs Host Disease/etiology ; Hematologic Diseases/diagnosis ; Hematologic Diseases/mortality ; Hematologic Diseases/therapy ; Hematopoietic Stem Cell Mobilization/methods ; Humans ; Infant ; Lymphocyte Depletion ; Male ; Retreatment ; Transplantation Chimera ; Transplantation, Homologous ; Treatment Outcome ; Young Adult
مستخلص: Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = 3) or haploidentical donors (n = 16) between 2003 and 2012. After total nodal irradiation (TNI)-based reconditioning combined with fludarabine, thiotepa and anti-T cell serotherapy, all patients received T cell-depleted peripheral blood stem cell grafts from a second, haploidentical donor. Median time between graft failure and retransplantation was 14 d (range 7-40). Sustained engraftment (median: 10 d, range 9-32) and complete donor chimerism was observed in all evaluable patients. 5 patients additionally received donor lymphocyte infusions. Graft-versus-host disease (GvHD) grade II and III occurred in 1 patient each (22%); no GvHD grade IV was observed. 2 patients had transient chronic GvHD. The regimen was well tolerated with transient interstitial pneumonitis in one patient. Treatment-related mortality after one year was 11%. Event-free survival and overall survival 3 years after retransplantation were 63% and 68%. Thus, a TNI-based reconditioning regimen followed by transplantation of haploidentical stem cells is an option to rescue patients with graft failure within a short time span and with low toxicity.
(© 2016 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: Haploidentical; T cell depletion; children; graft failure; stem cell transplantation
المشرفين على المادة: 0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20160625 Date Completed: 20170515 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5132112
DOI: 10.1111/bjh.14190
PMID: 27341180
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2141
DOI:10.1111/bjh.14190