دورية أكاديمية
أعرض في EDS

Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.

التفاصيل البيبلوغرافية
العنوان: Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.
المؤلفون: Simonin L; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France.; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Pasquier E; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Leroyer C; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Cornec D; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France.; Unit of Rheumatology, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Lemerle J; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France., Bendaoud B; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Hillion S; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Pers JO; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Couturaud F; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Renaudineau Y; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France. yves.renaudineau@univ-brest.fr.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France. yves.renaudineau@univ-brest.fr.
المصدر: Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2017 Aug; Vol. 53 (1), pp. 14-27.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9504368 Publication Model: Print Cited Medium: Internet ISSN: 1559-0267 (Electronic) Linking ISSN: 10800549 NLM ISO Abbreviation: Clin Rev Allergy Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Totowa, NJ : Humana Press, c1995-
مواضيع طبية MeSH: Lymphocyte Count*, Antiphospholipid Syndrome/*blood , Antiphospholipid Syndrome/*immunology , Lymphocyte Subsets/*immunology , Venous Thromboembolism/*blood , Venous Thromboembolism/*immunology, Animals ; Antiphospholipid Syndrome/diagnosis ; Autoimmunity ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; Biomarkers ; Humans ; Immunophenotyping ; Lymphocyte Subsets/metabolism ; Serologic Tests ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Venous Thromboembolism/diagnosis
مستخلص: Among patients with venous thromboembolism (VTE), the persistent detection of antiphospholipid (aPL) antibodies (Ab) represents an independent high risk factor for recurrence. However, oral anticoagulation vitamin K antagonist therapy, frequently used in these patients, is problematic in assessing and/or confirming a diagnosis of primary aPL syndrome (pAPS), suggesting use of alternative strategies. For this reason, and by analogy with other autoimmune diseases, a flow cytometer approach testing peripheral T cell subsets (CD3, CD4, and CD8), B cell subsets (B1, transitional, naive, and memory), and NK cells can be proposed. As an example and to validate the concept, pAPS patients selected from the monocentric VTE case-control EDITH's cohort were selected during their follow-up. As suspected and in contrast to non-APS VTE patients, other autoimmune diseases, and controls, pAPS VTE patients displayed specific lymphocyte disturbances. Quantitative and qualitative modifications were related to total CD4 + T cell reduction, a lower CD4/CD8 ratio, and disturbance in B cell homeostasis with increased proportions of B1 cells, transitional B cells (CD24 ++ CD38 ++ ), and naive B cells (IgD + CD27 - ), while memory B cells (IgD + CD27 + and IgD - CD27 + ) were reduced. Interestingly, the absolute number of CD4 + T cells positively correlated with IgG anti-cardiolipin Ab levels. Altogether, disturbances of T and B cell homeostasis characterized pAPS VTE patients during their follow-up. This suggests a means of profiling that could be used in addition to existing criteria to characterize them.
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فهرسة مساهمة: Keywords: Antiphospholipid syndrome; Autoimmunity; B cells; Lymphocytes; Venous thromboembolism
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20160626 Date Completed: 20180329 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s12016-016-8568-1
PMID: 27342459
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0267
DOI:10.1007/s12016-016-8568-1