دورية أكاديمية
أعرض في EDS

Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity.

التفاصيل البيبلوغرافية
العنوان: Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity.
المؤلفون: Broadley SP; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany; Institute for Systemic Inflammation Research, Universität zu Lübeck, 23538 Lübeck, Germany., Plaumann A; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany., Coletti R; Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Lehmann C; Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Wanisch A; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany., Seidlmeier A; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany., Esser K; Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany., Luo S; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany; Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany., Rämer PC; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany., Massberg S; Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany., Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany; Focus Group 'Clinical Cell Processing and Purification,' Institute for Advanced Study, Technische Universität München, 85748 Garching, Germany; National Center for Infection Research, 81675 Munich, Germany., van Lookeren Campagne M; Immunology Department, Genentech, Inc., South San Francisco, CA 94080, USA., Verschoor A; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany; Institute for Systemic Inflammation Research, Universität zu Lübeck, 23538 Lübeck, Germany. Electronic address: admar.verschoor@uksh.de.
المصدر: Cell host & microbe [Cell Host Microbe] 2016 Jul 13; Vol. 20 (1), pp. 36-48. Date of Electronic Publication: 2016 Jun 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press
مواضيع طبية MeSH: Adaptive Immunity* , Bacterial Adhesion*, Bacteremia/*immunology , Blood/*microbiology , Blood Platelets/*microbiology , Listeria monocytogenes/*immunology , Receptors, Complement/*metabolism, Animals ; Intravital Microscopy ; Mice, Inbred C57BL ; Mice, Knockout ; Time Factors
مستخلص: Efficient clearance of bacteremia prevents life-threatening disease. Platelet binding to intravascular bacteria, a process involving platelet glycoprotein GPIb and bacterial opsonization with activated complement C3, influences blood clearance and anti-infective immunity. Using intravital microscopy of the bloodstream of mice infected with Listeria monocytogenes, we show that bacterial clearance is not a uniform process but a "dual-track" mechanism consisting of parallel "fast" and "slow" pathways. "Slow clearance" is regulated by time-dependent bacterial opsonization, stochastic platelet binding, and capture of bacteria-platelet-complexes via the complement receptor of the immunoglobulin superfamily, CRIg. The mechanism spares some bacteria from "fast clearance" and rapid destruction in the liver via Kupffer cell scavenger receptors, keeping them available for adaptive immunity induction by splenic CD8α(+) dendritic cells. We consistently find "fast" and "slow" clearance patterns for a broad panel of other Gram+ and Gram- bacteria. Thus, dual-track clearance balances rapid restoration of blood sterility with induction of specific antibacterial immunity.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Cell Host Microbe. 2016 Jul 13;20(1):1-2. (PMID: 27414492)
المشرفين على المادة: 0 (Receptors, Complement)
0 (VSIG4 protein, mouse)
تواريخ الأحداث: Date Created: 20160628 Date Completed: 20170825 Latest Revision: 20200930
رمز التحديث: 20231215
DOI: 10.1016/j.chom.2016.05.023
PMID: 27345696
قاعدة البيانات: MEDLINE
الوصف
تدمد:1934-6069
DOI:10.1016/j.chom.2016.05.023