دورية أكاديمية
New ent-kaurane diterpenoid dimer from Pulicaria inuloides.
| العنوان: | New ent-kaurane diterpenoid dimer from Pulicaria inuloides. |
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| المؤلفون: | Galala AA; a Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt., Sallam A; a Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt., Abdel-Halim OB; a Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt.; b Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy , Taibah University , Al madinah Almonwwarah , Saudi Arabia., Gedara SR; a Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt. |
| المصدر: | Natural product research [Nat Prod Res] 2016 Nov; Vol. 30 (21), pp. 2468-75. Date of Electronic Publication: 2016 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Diterpenes, Kaurane/*isolation & purification , Pulicaria/*chemistry, Anti-Infective Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Diterpenes, Kaurane/chemistry ; Diterpenes, Kaurane/pharmacology ; Hep G2 Cells ; Humans ; Plant Components, Aerial/chemistry |
| مستخلص: | A new naturally occurring ent-kaurane diterpenoid dimer, 15β, 15'β-oxybis (ent-kaur-16-en-19-oic acid) (1) along with six known compounds, 15β-hydroxy-ent-kaur-16-en-19-oic acid (2), 15β-hydroxy-ent-kaur-16-en-19-oate-β-d-glucopyranoside (3), 6-hydroxykaempferol-3, 7-dimethyl ether (4), quercetagetin 3, 7, 3'-trimethyl ether (5), β-sitosterol (6) and β-sitosterol glucoside (daucosterol) (7) were isolated from the aerial parts of Pulicaria inuloides DC. Compounds 2-5 were isolated for the first time from genus Pulicaria. The structures of compounds 1-7 were established on the basis of extensive 1D and 2D NMR spectroscopic techniques in combination with ESI-MS. The antimicrobial activity of the isolated compounds was evaluated against Staphylococcus aureus, Escherichia coli and Candida albicans. Sulphorhodamine B cytotoxic assay against HepG2 (liver cancer) cell line and ABTS antioxidant assay were carried out. |
| فهرسة مساهمة: | Keywords: Asteraceae; Pulicaria inuloides; antimicrobial; antioxidant; cytotoxicity; ent-kaurane |
| المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Antineoplastic Agents, Phytogenic) 0 (Diterpenes, Kaurane) |
| تواريخ الأحداث: | Date Created: 20160628 Date Completed: 20170424 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2016.1201671 |
| PMID: | 27348493 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2016.1201671 |