دورية أكاديمية
أعرض في EDS

Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results.

التفاصيل البيبلوغرافية
العنوان: Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results.
المؤلفون: Tekle AH; African Programme for Onchocerciasis Control, Ouagadougou, Burkina Faso., Zouré HG; African Programme for Onchocerciasis Control, Ouagadougou, Burkina Faso., Noma M; African Programme for Onchocerciasis Control, Ouagadougou, Burkina Faso., Boussinesq M; Institut de Recherche pour le Développement (IRD), Montpellier, France., Coffeng LE; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Stolk WA; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Remme JH; 120 rue des Campanules, Ornex, France. hansremme@gmail.com.
المصدر: Infectious diseases of poverty [Infect Dis Poverty] 2016 Jun 27; Vol. 5 (1), pp. 66. Date of Electronic Publication: 2016 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101606645 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-9957 (Electronic) Linking ISSN: 20499957 NLM ISO Abbreviation: Infect Dis Poverty Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2012-
مواضيع طبية MeSH: Filaricides/*therapeutic use , Ivermectin/*therapeutic use , Onchocerciasis/*epidemiology , Onchocerciasis/*prevention & control, Africa South of the Sahara/epidemiology ; Animals ; Bayes Theorem ; Community Health Services ; Filaricides/pharmacology ; Ivermectin/pharmacology ; Microfilariae/drug effects ; Monte Carlo Method ; Onchocerca volvulus/drug effects ; Onchocerciasis/drug therapy ; Onchocerciasis/parasitology ; Prevalence
مستخلص: Background: The African Programme for Onchocerciasis Control (APOC) was created in 1995 to establish community-directed treatment with ivermectin (CDTi) in order to control onchocerciasis as a public health problem in 20 African countries that had 80 % of the global disease burden. When research showed that CDTi may ultimately eliminate onchocerciasis infection, APOC was given in 2008 the additional objective to determine when and where treatment can be safely stopped. We report the results of epidemiological evaluations undertaken from 2008 to 2014 to assess progress towards elimination in CDTi areas with ≥6 years treatment.
Methods: Skin snip surveys were undertaken in samples of first-line villages to determine the prevalence of O. volvulus microfilariae. There were two evaluation phases. The decline in prevalence was evaluated in phase 1A. Observed and model-predicted prevalences were compared after correcting for endemicity level and treatment coverage. Bayesian statistics and Monte Carlo simulation were used to classify the decline in prevalence as faster than predicted, on track or delayed. Where the prevalence approached elimination levels, phase 1B was launched to determine if treatment could be safely stopped. Village sampling was extended to the whole CDTi area. Survey data were analysed within a Bayesian framework to determine if stopping criteria (overall prevalence <1.4 % and maximum stratum prevalence <5 %) were met.
Results: In phase 1A 127 665 people from 639 villages in 54 areas were examined. The prevalence had fallen dramatically. The decline in prevalence was faster than predicted in 23 areas, on track in another 23 and delayed in eight areas. In phase 1B 108 636 people in 392 villages were examined in 22 areas of which 13 met the epidemiological criteria for stopping treatment. Overall, 32 areas (25.4 million people) had reached or were close to elimination, 18 areas (17.4 million) were on track but required more years treatment, and in eight areas (10.4 million) progress was unsatisfactory.
Conclusions: Onchocerciasis has been largely controlled as a public health problem. Great progress has been made towards elimination which already appears to have been achieved for millions of people. For most APOC countries, nationwide onchocerciasis elimination is within reach.
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فهرسة مساهمة: Keywords: APOC; Community-directed treatment; Elimination; Ivermectin; ONCHOSIM; Onchocerciasis
المشرفين على المادة: 0 (Filaricides)
70288-86-7 (Ivermectin)
تواريخ الأحداث: Date Created: 20160629 Date Completed: 20170207 Latest Revision: 20220409
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4924267
DOI: 10.1186/s40249-016-0160-7
PMID: 27349645
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9957
DOI:10.1186/s40249-016-0160-7