دورية أكاديمية
Central serous chorioretinopathy in primary hyperaldosteronism.
| العنوان: | Central serous chorioretinopathy in primary hyperaldosteronism. |
|---|---|
| المؤلفون: | van Dijk EH; Department of Ophthalmology, Leiden University Medical Center, Department J3-S, PO Box 9600, 2300RC, Leiden, Netherlands., Nijhoff MF; Department of Medicine, Division of Nephrology and Transplantation, Leiden University Medical Center, Leiden, Netherlands.; Department of Medicine, Division of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands., de Jong EK; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, Netherlands., Meijer OC; Department of Medicine, Division of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., de Vries AP; Department of Medicine, Division of Nephrology and Transplantation, Leiden University Medical Center, Leiden, Netherlands., Boon CJ; Department of Ophthalmology, Leiden University Medical Center, Department J3-S, PO Box 9600, 2300RC, Leiden, Netherlands. c.j.f.boon@lumc.nl. |
| المصدر: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2016 Oct; Vol. 254 (10), pp. 2033-2042. Date of Electronic Publication: 2016 Jul 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c1982- |
| مواضيع طبية MeSH: | Central Serous Chorioretinopathy/*etiology , Hyperaldosteronism/*complications, Adult ; Aged ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Humans ; Hyperaldosteronism/diagnosis ; Hypertension/complications ; Hypertension/diagnosis ; Male ; Middle Aged ; Photochemotherapy ; Subretinal Fluid ; Tomography, Optical Coherence |
| مستخلص: | Purpose: To describe ophthalmological characteristics of 13 patients with primary hyperaldosteronism (PA). Methods: Cross-sectional study. All patients underwent extensive ophthalmological examination. Results: Thirteen PA patients (9 male, 4 female) were diagnosed with arterial hypertension for 11.0 ± 11.2 years. Ophthalmological imaging revealed macular serous subretinal fluid (SRF) on optical coherence tomography in 2 patients (15 %). In one of these patients, bilateral chronic central serous chorioretinopathy (CSC) with polypoidal choroidal neovasculopathy was diagnosed, which was effectively treated with full-dose photodynamic therapy. In the other patient with SRF and bilateral diffuse hyperfluorescent areas on fluorescein angiography, the SRF had decreased spontaneously after 6 weeks of follow-up. In 5 of the remaining patients (38 %), retinal pigment epithelium alterations resembling findings characteristic for CSC were seen on multimodal imaging. The mean subfoveal choroidal thickness was 290.2 ± 65.0 μm. Conclusions: Retinal abnormalities resembling (subclinical) CSC are common in patients with PA. These findings indicate that mineralocorticoid-mediated pathways are involved in the pathogenesis of CSC. In CSC patients with hypertension of unknown origin, a diagnosis of PA should be considered. Competing Interests: Compliance with ethical standards All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This research was supported by the following foundations: MaculaVereniging, Landelijke Stichting voor Blinden en Slechtzienden, Retina Netherlands, and BlindenPenning, that contributed through UitZicht. The funding organizations had no role in the design or conduct of this research. They provided unrestricted grants. Conflict of interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. |
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| فهرسة مساهمة: | Keywords: Central serous chorioretinopathy; Cross-sectional study; Eplerenone; Hyperaldosteronism; Mineralocorticoid antagonist; Spironolactone |
| تواريخ الأحداث: | Date Created: 20160710 Date Completed: 20170420 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5045484 |
| DOI: | 10.1007/s00417-016-3417-8 |
| PMID: | 27393297 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1435-702X |
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| DOI: | 10.1007/s00417-016-3417-8 |