دورية أكاديمية
Effectiveness of nutritional treatment and synbiotic use on gastrointestinal symptoms reduction in HIV-infected patients: Randomized clinical trial.
| العنوان: | Effectiveness of nutritional treatment and synbiotic use on gastrointestinal symptoms reduction in HIV-infected patients: Randomized clinical trial. |
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| المؤلفون: | Santos ASEAC; Post-Graduation Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Goias, Brazil. Electronic address: annelisa.nut@gmail.com., Silveira EAD; Post-Graduation Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Brazil. Electronic address: erikasil@terra.com.br., Falco MO; Post-Graduation Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Brazil. Electronic address: mariannefalco@hotmail.com., Nery MW; Faculty of Medicine, Pontifical Catholic University of Goias, Brazil. Electronic address: maxwnery@uol.com.br., Turchi MD; Institute of Tropical Pathology and Public Health, Federal University of Goias, Brazil. Electronic address: marilia.turchi@gmail.com. |
| المصدر: | Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2017 Jun; Vol. 36 (3), pp. 680-685. Date of Electronic Publication: 2016 Jun 23. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982- |
| مواضيع طبية MeSH: | Diet*, Gastrointestinal Diseases/*prevention & control , HIV Infections/*therapy , Synbiotics/*administration & dosage, Adult ; Bifidobacterium ; Double-Blind Method ; Female ; Humans ; Lactobacillus ; Male ; Middle Aged ; Oligosaccharides/administration & dosage ; Quality of Life ; Socioeconomic Factors ; Treatment Outcome ; Young Adult |
| مستخلص: | Background & Aims: Gastrointestinal symptoms are among the most frequent reported complaints by people living with HIV and AIDS (PLWHA). Treatments that aim to attenuate these symptoms are important to avoid low adherence to antiretroviral therapy and to improve the quality of life. This study aimed to evaluate the effectiveness of nutritional treatment and synbiotic use in PLWHA on reducing gastrointestinal symptoms. Methods: A randomized clinical trial nested to an outpatient cohort was conducted to evaluate the effectiveness of two treatments for gastrointestinal symptoms reduction in adult patients with antiretroviral therapy presenting at least one gastrointestinal symptom: 1) nutritional treatment + placebo (6 g maltodextrin) and 2) nutritional treatment + synbiotic (Lactobacillus and Bifidobacterium strains + 6 g fructooligosaccharides). Placebo and synbiotic were consumed twice a day during six months. The primary outcome variable was percentage reduction in the incidence of diarrhea, and secondary outcomes the decrease in the incidence of nausea and/or vomiting, dyspepsia, heartburn, constipation, flatulence, and the presence of three or more gastrointestinal symptoms. Results: Out of 283 patients evaluated for eligibility, 64 met inclusion criteria to enter in this study with 1:1 allocation ratio. Both analyzed groups were homogeneous regarding sociodemographic, clinical and lifestyle variables at baseline. In the intergroup analysis, no difference was found between groups except for heartburn, which had a higher reduction in the placebo group (0.01). Regarding the intragroup analysis, in the placebo group a significant decrease in diarrhea (p = 0.02) and heartburn (p < 0.01) were observed while there was a significant reduction for nausea e/or vomit (p = 0.01), dyspepsia (p = 0.10), diarrhea (p = 0.01) and constipation (p = 0.08) in the synbiotic group. Conclusions: Diarrhea decreased in both groups, but no statistical difference between treatments was observed. The use of synbiotic appeared to reduce a greater number of symptoms although there were no statistical differences in the intergroup analysis. This clinical trial was registered at ClinicalTrials.gov (NCT02180035). (Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ART; Diet therapy; Gastrointestinal symptoms; HIV; Synbiotic |
| سلسلة جزيئية: | ClinicalTrials.gov NCT02180035 |
| المشرفين على المادة: | 0 (Oligosaccharides) 0 (fructooligosaccharide) |
| تواريخ الأحداث: | Date Created: 20160711 Date Completed: 20180323 Latest Revision: 20180323 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clnu.2016.06.005 |
| PMID: | 27395330 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1983 |
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| DOI: | 10.1016/j.clnu.2016.06.005 |