دورية أكاديمية
أعرض في EDS

Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach.

التفاصيل البيبلوغرافية
العنوان: Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach.
المؤلفون: Franco FC; Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Alves AA; Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Godoy FR; Núcleo de Pesquisas Replicon, Departamento de Biologia, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil., Avelar JB; Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Rodrigues DD; Núcleo de Pesquisas Replicon, Departamento de Biologia, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil., Pedroso TM; Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., da Cruz AD; Núcleo de Pesquisas Replicon, Departamento de Biologia, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil., Nomura F; Campus II, Itatiaia, Departamento de Genética, Instituto de Ciências Biológicas 1, Universidade Federal de Goiás, Goiânia, Goiás, Cep 74001-970, Brazil., de Melo E Silva D; Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. silvadanielamelo@gmail.com.; Campus II, Itatiaia, Departamento de Genética, Instituto de Ciências Biológicas 1, Universidade Federal de Goiás, Goiânia, Goiás, Cep 74001-970, Brazil. silvadanielamelo@gmail.com.; Programa de Pós-Graduação em Ciências Ambientais, Laboratório de Mutagênese e Radiobiologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. silvadanielamelo@gmail.com.; Programa de Pós-Graduação em Biodiversidade Animal, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. silvadanielamelo@gmail.com.
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2016 Oct; Vol. 23 (19), pp. 19723-34. Date of Electronic Publication: 2016 Jul 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: Occupational Exposure/*analysis , Pesticides/*metabolism, Adult ; Biomarkers/metabolism ; Brazil ; Comet Assay ; DNA Damage ; Genotype ; Glutathione Transferase/genetics ; Glutathione Transferase/metabolism ; Humans ; Male ; Occupational Exposure/statistics & numerical data ; Pesticides/analysis ; Public Health ; Risk
مستخلص: This is the first study demonstrating genotoxic effects and whole transcriptome analysis on community health agents (CHAs) occupationally exposed to pesticides in Central Brazil. For the transcriptome analysis, we found some genes related to Alzheimer's disease (LRP1), an insulin-like growth factor receptor (IGF2R), immunity genes (IGL family and IGJ), two genes related to inflammatory reaction (CXCL5 and CCL3), one gene related to maintenance of cellular morphology (NHS), one gene considered to be a strong apoptosis inductor (LGALS14), and several transcripts of the neuroblastoma breakpoint family (NBPF). Related to comet assay, we demonstrated a significant increase in DNA damage, measured by the olive tail moment (OTM), in the exposed group compared to the control group. Moreover, we also observed a statistically significant difference in OTM values depending on GSTM1 genotypes. Therefore, Brazilian epidemiological surveillance, an organization responsible for the assessment and management of health risks associated to pesticide exposure to CHA, needs to be more proactive and considers the implications of pesticide exposure for CHA procedures and processes.
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فهرسة مساهمة: Keywords: Comet assay; DNA damage; Differential expression panel; GST genotypes; Occupational exposure; Pesticide genotoxicity
المشرفين على المادة: 0 (Biomarkers)
0 (Pesticides)
EC 2.5.1.18 (Glutathione Transferase)
EC 2.5.1.18 (glutathione S-transferase M1)
تواريخ الأحداث: Date Created: 20160714 Date Completed: 20170425 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1007/s11356-016-7179-y
PMID: 27406225
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-016-7179-y