دورية أكاديمية
أعرض في EDS

Paroxetine exposure skews litter sex ratios in mice suggesting a Trivers-Willard process.

التفاصيل البيبلوغرافية
العنوان: Paroxetine exposure skews litter sex ratios in mice suggesting a Trivers-Willard process.
المؤلفون: Gaukler SM; Department of Biology, University of Utah , 257 South 1400 East, Salt Lake City, UT 84112 , USA., Ruff JS; Department of Biology, University of Utah , 257 South 1400 East, Salt Lake City, UT 84112 , USA., Potts WK; Department of Biology, University of Utah , 257 South 1400 East, Salt Lake City, UT 84112 , USA.
المصدر: Behavioral ecology : official journal of the International Society for Behavioral Ecology [Behav Ecol] 2016 Jul-Aug; Vol. 27 (4), pp. 1113-1121. Date of Electronic Publication: 2016 Feb 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9426330 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1045-2249 (Print) Linking ISSN: 10452249 NLM ISO Abbreviation: Behav Ecol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Oxford University Press, c1990-
مستخلص: While conducting a toxicity assessment of the antidepressant paroxetine (Paxil®), in wild-derived mice ( Mus musculus ), we observed that exposed dams (P 0 ) produced female biased litters (32:68 M:F). Though numerous experimental manipulations have induced sex ratio bias in mice, none have assessed the fitness of the offspring from these litters relative to controls. Here, we retrospectively analyze experimentally derived fitness data gathered for the purpose of toxicological assessment in light of 2 leading hypothesis (Trivers-Willard hypothesis [TWH] and cost of reproduction hypothesis [CRH]), seeking to test if this facultative sex ratio adjustment fits into an adaptive framework. Control F 1 males were heavier than F 1 females, but no differences in mass were detected between exposed F 1 males and females, suggesting that exposed dams did not save energy by producing fewer males, despite producing 29.2% lighter litters relative to controls. F 1 offspring of both treatments were released into seminatural enclosures where fitness was quantified. In enclosures, the relative reproductive success of F 1 -exposed males (compared with controls) was reduced by ~20% compared with the relative reproductive success of F 1 -exposed females. Thus, exposed dams increased their fitness by adjusting litters toward females who were less negatively affected by the exposure than males. Collectively, these data provide less support that the observed sex ratio bias results in energetic savings (CRH), and more support for the TWH because fitness was increased by biasing litters toward female offspring. These mammalian data are unique in their ability to support the TWH through the use of relevant fitness data.
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معلومات مُعتمدة: R01 GM109500 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: SSRI.; adaptive sex allocation; cost of reproduction hypothesis; fitness assay; paroxetine
تواريخ الأحداث: Date Created: 20160716 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4943110
DOI: 10.1093/beheco/arw017
PMID: 27418753
قاعدة البيانات: MEDLINE
الوصف
تدمد:1045-2249
DOI:10.1093/beheco/arw017