دورية أكاديمية
Estrogen receptor genes in gastropods: phylogenetic divergence and gene expression responses to a synthetic estrogen.
| العنوان: | Estrogen receptor genes in gastropods: phylogenetic divergence and gene expression responses to a synthetic estrogen. |
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| المؤلفون: | Hultin CL; Centre for Environmental and Climate Research (CEC), Lund University, Sölvegatan 37, SE-22362 Lund, Sweden. Electronic address: Cecilia.hultin@cec.lu.se., Hallgren P; Department of Biology, Lund University, Sölvegatan 37, SE-22362 Lund, Sweden., Hansson MC; Centre for Environmental and Climate Research (CEC), Lund University, Sölvegatan 37, SE-22362 Lund, Sweden. |
| المصدر: | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2016 Nov; Vol. 189, pp. 17-21. Date of Electronic Publication: 2016 Jul 15. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 100959500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0456 (Print) Linking ISSN: 15320456 NLM ISO Abbreviation: Comp Biochem Physiol C Toxicol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science, c2000- |
| مواضيع طبية MeSH: | Evolution, Molecular* , Phylogeny*, Endocrine Disruptors/*toxicity , Estrogens/*toxicity , Ethinyl Estradiol/*toxicity , Gastropoda/*drug effects , Gastropoda/*genetics , Receptors, Estrogen/*drug effects , Receptors, Estrogen/*genetics, Animals ; Gastropoda/classification ; Gastropoda/metabolism ; Gene Expression Regulation/drug effects ; Receptors, Estrogen/metabolism ; Transcription, Genetic/drug effects |
| مستخلص: | Endocrine disrupting chemicals (EDCs) have the potential to affect development and reproduction in gastropods. However, one is today lacking basic understanding of the Molluscan endocrine system and one can therefore not fully explain these EDC-induced affects. Furthermore, only a few genes that potentially may be connected to the endocrine system have been sequenced in gastropods. An example is the estrogen receptor gene (er) that have been identified in a restricted number of freshwater and marine gastropods. Here, we have identified a new partial coding sequence of an estrogen receptor gene (er) in the European common heterobranch Radix balthica. The following phylogenetic analysis divided the ers of heterobranchs and ceanogastropods in two branches. Furthermore, exposure to the synthetic estrogen 17α-ethinylestradiol (EE2) showed that exposure could significantly affect er expression level in the heterobranch R. balthica. This paper is the first that phylogenetically compares gastropods' er, basal er expression profiles, and transcriptional estrogenic responses in gastropods from two different evolutionary groups. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 17α-Ethinylestradiol; Estrogen receptor; Gastropods; Phylogenetic analysis |
| المشرفين على المادة: | 0 (Endocrine Disruptors) 0 (Estrogens) 0 (Receptors, Estrogen) 423D2T571U (Ethinyl Estradiol) |
| تواريخ الأحداث: | Date Created: 20160719 Date Completed: 20170213 Latest Revision: 20170213 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.cbpc.2016.07.002 |
| PMID: | 27426037 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-0456 |
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| DOI: | 10.1016/j.cbpc.2016.07.002 |