دورية أكاديمية
Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation.
| العنوان: | Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation. |
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| المؤلفون: | Patil-Sen Y; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK., Dennison SR; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK., Snape TJ; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK. Electronic address: tjsnape@uclan.ac.uk. |
| المصدر: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Sep 15; Vol. 24 (18), pp. 4241-4245. Date of Electronic Publication: 2016 Jul 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford : New York : Pergamon Press, c1993- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Cell Membrane/*drug effects , Methylurea Compounds/*pharmacology , Phenylurea Compounds/*pharmacology , Surface-Active Agents/*pharmacology, Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Cell Membrane/metabolism ; Cell Membrane Permeability ; Escherichia coli/drug effects ; Methylurea Compounds/chemical synthesis ; Methylurea Compounds/chemistry ; Molecular Conformation ; Molecular Structure ; Phenylurea Compounds/chemical synthesis ; Phenylurea Compounds/chemistry ; Polymyxin B/pharmacology ; Staphylococcus aureus/drug effects ; Surface-Active Agents/chemical synthesis ; Surface-Active Agents/chemistry |
| مستخلص: | By varying the molecular charge, shape and amphiphilicity of a series of conformationally distinct diarylureas it is possible to control the levels of phospholipid membrane lysis using membranes composed of bacterial lipid extracts. From the data obtained, it appears as though the lysis activity observed is not due to charge, conformation or amphiphilicity in isolation, but that surface aggregation, H-bonding and other factors may also play a part. The work provides evidence that this class of foldamer possesses potential for optimisation into new antibacterial agents. (Copyright © 2016 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antibacterial; Conformation; Diarylureas; Foldamer; Membrane |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Methylurea Compounds) 0 (Phenylurea Compounds) 0 (Surface-Active Agents) J2VZ07J96K (Polymyxin B) |
| تواريخ الأحداث: | Date Created: 20160719 Date Completed: 20170726 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bmc.2016.07.017 |
| PMID: | 27427397 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3391 |
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| DOI: | 10.1016/j.bmc.2016.07.017 |