دورية أكاديمية
أعرض في EDS

The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection.

التفاصيل البيبلوغرافية
العنوان: The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection.
المؤلفون: Snezhkina AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Krasnov GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia; Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119121, Russia., Lipatova AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Sadritdinova AF; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia; National Medical Research Center of Radiology, Ministry of Healthcare of the Russian Federation, Moscow 125284, Russia., Kardymon OL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Fedorova MS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Melnikova NV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Stepanov OA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Zaretsky AR; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia., Kaprin AD; National Medical Research Center of Radiology, Ministry of Healthcare of the Russian Federation, Moscow 125284, Russia., Alekseev BY; National Medical Research Center of Radiology, Ministry of Healthcare of the Russian Federation, Moscow 125284, Russia., Dmitriev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia; National Medical Research Center of Radiology, Ministry of Healthcare of the Russian Federation, Moscow 125284, Russia.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2016; Vol. 2016, pp. 2353560. Date of Electronic Publication: 2016 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Bacteroides Infections/*pathology , Bacteroides fragilis/*isolation & purification , CCAAT-Enhancer-Binding Protein-beta/*biosynthesis , Colorectal Neoplasms/*metabolism , Colorectal Neoplasms/*microbiology , Polyamines/*metabolism , Proto-Oncogene Proteins c-myc/*biosynthesis, Bacteroides Infections/genetics ; Bacteroides Infections/metabolism ; Bacteroides Infections/microbiology ; CCAAT-Enhancer-Binding Protein-beta/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Gene Expression ; Genes, myc ; Humans ; Oxidoreductases Acting on CH-NH Group Donors/biosynthesis ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Polyamine Oxidase
مستخلص: Colorectal cancer is one of the most common cancers in the world. It is well known that the chronic inflammation can promote the progression of colorectal cancer (CRC). Recently, a number of studies revealed a potential association between colorectal inflammation, cancer progression, and infection caused by enterotoxigenic Bacteroides fragilis (ETBF). Bacterial enterotoxin activates spermine oxidase (SMO), which produces spermidine and H2O2 as byproducts of polyamine catabolism, which, in turn, enhances inflammation and tissue injury. Using qPCR analysis, we estimated the expression of SMOX gene and ETBF colonization in CRC patients. We found no statistically significant associations between them. Then we selected genes involved in polyamine metabolism, metabolic reprogramming, and inflammation regulation and estimated their expression in CRC. We observed overexpression of SMOX, ODC1, SRM, SMS, MTAP, c-Myc, C/EBPβ (CREBP), and other genes. We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets. Thus, increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPβ rather than ETBF infection.
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المشرفين على المادة: 0 (CCAAT-Enhancer-Binding Protein-beta)
0 (MYC protein, human)
0 (Polyamines)
0 (Proto-Oncogene Proteins c-myc)
EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors)
تواريخ الأحداث: Date Created: 20160720 Date Completed: 20170714 Latest Revision: 20231213
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4940579
DOI: 10.1155/2016/2353560
PMID: 27433286
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2016/2353560