دورية أكاديمية
أعرض في EDS

Antiproliferative and toxicological properties of methanolic extract obtained from Solanum capsicoides All. seeds and carpesterol.

التفاصيل البيبلوغرافية
العنوان: Antiproliferative and toxicological properties of methanolic extract obtained from Solanum capsicoides All. seeds and carpesterol.
المؤلفون: Petreanu M; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Guimarães ÁA; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Broering MF; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Ferreira EK; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Machado ID; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Gois AL; Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA)-Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil., de Carvalho JE; Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA)-Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil., Monache FD; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Niero R; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil., Santin JR; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil. jrs.santin@univali.br.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2016 Oct; Vol. 389 (10), pp. 1123-31. Date of Electronic Publication: 2016 Jul 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Seeds*/chemistry , Solanum*/chemistry, Antineoplastic Agents, Phytogenic/*pharmacology , Cell Proliferation/*drug effects , Methanol/*chemistry , Neoplasms/*drug therapy , Phytosterols/*pharmacology , Plant Extracts/*pharmacology , Solvents/*chemistry, Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/toxicity ; Female ; Hemolysis/drug effects ; Humans ; K562 Cells ; Lethal Dose 50 ; MCF-7 Cells ; Mice ; Micronucleus Tests ; Neoplasms/pathology ; Phytosterols/isolation & purification ; Phytosterols/toxicity ; Phytotherapy ; Plant Extracts/isolation & purification ; Plant Extracts/toxicity ; Plants, Medicinal
مستخلص: Natural products are considered important sources of potential chemotherapeutic agents. Here, we evaluated the antiproliferative activity and the toxicological effects of the methanolic extract and a pure compound obtained from Solanum capsicoides seeds. The phytochemical profile was analyzed by chromatographic and spectroscopy methods. The acute toxicity was assessed in mice orally treated with the extract (2000 mg/kg), in vitro hemolytic activity and micronucleus test. The mutagenicity, developmental toxicity, and lethal dose (LD50) of carpesterol were estimated by the Toxicity Estimation Software Tool (TEST) software. A sulforhodamine B assay was employed to evaluate the antiproliferative activity. The toxicological assays did not observe signs of toxicity, either during the behavioral observations or in the autopsies, as well as no mutagenicity and hemolytic activity. The carpesterol did not present mutagenic effect and hemolytic activity but presents developmental toxicology and LD50 of 410 mg/kg in toxicity estimations by the TEST software. The S. capsicoides extract exhibited antiproliferative activity mainly in leukemia (K562) cell lineage. However, carpesterol presented antiproliferative activity in glioma (U251), breast (MCF-7), kidney (786-0), ovary (OVCAR-03), and K562 cell lineages. The data obtained show that S. capsicoides extract presents antiproliferative and does not present toxicological effects. In addition, it was shown for the first time the antiproliferative and toxicological parameters of carpesterol.
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فهرسة مساهمة: Keywords: Cancer; Cytotoxicity; Mutagenicity; Natural compound
المشرفين على المادة: 0 (Antineoplastic Agents, Phytogenic)
0 (Phytosterols)
0 (Plant Extracts)
0 (Solvents)
0 (carpesterol)
Y4S76JWI15 (Methanol)
تواريخ الأحداث: Date Created: 20160721 Date Completed: 20170223 Latest Revision: 20181113
رمز التحديث: 20221213
DOI: 10.1007/s00210-016-1275-x
PMID: 27438483
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1912
DOI:10.1007/s00210-016-1275-x