دورية أكاديمية
African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004-2014.
| العنوان: | African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004-2014. |
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| المؤلفون: | Weyer CT, Grewar JD, Burger P, Rossouw E, Lourens C, Joone C, le Grange M, Coetzee P, Venter E, Martin DP, MacLachlan NJ, Guthrie AJ |
| المصدر: | Emerging infectious diseases [Emerg Infect Dis] 2016 Dec; Vol. 22 (12), pp. 2087-2096. Date of Electronic Publication: 2016 Dec 15. |
| نوع المنشور: | Historical Article; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
| مواضيع طبية MeSH: | Genome, Viral* , Reassortant Viruses*/genetics , Reassortant Viruses*/immunology , Vaccines, Attenuated*/genetics , Vaccines, Attenuated*/immunology , Viral Vaccines*/genetics , Viral Vaccines*/immunology, African Horse Sickness/*epidemiology , African Horse Sickness/*virology , African Horse Sickness Virus/*genetics , African Horse Sickness Virus/*immunology, African Horse Sickness/history ; African Horse Sickness/prevention & control ; African Horse Sickness Virus/classification ; African Horse Sickness Virus/pathogenicity ; Animals ; Disease Outbreaks ; Genotype ; History, 21st Century ; Horses ; Phylogeny ; Polymorphism, Single Nucleotide ; Serotyping ; South Africa/epidemiology ; Whole Genome Sequencing |
| مستخلص: | African horse sickness (AHS) is a hemorrhagic viral fever of horses. It is the only equine disease for which the World Organization for Animal Health has introduced specific guidelines for member countries seeking official recognition of disease-free status. Since 1997, South Africa has maintained an AHS controlled area; however, sporadic outbreaks of AHS have occurred in this area. We compared the whole genome sequences of 39 AHS viruses (AHSVs) from field AHS cases to determine the source of 3 such outbreaks. Our analysis confirmed that individual outbreaks were caused by virulent revertants of AHSV type 1 live, attenuated vaccine (LAV) and reassortants with genome segments derived from AHSV types 1, 3, and 4 from a LAV used in South Africa. These findings show that despite effective protection of vaccinated horses, polyvalent LAV may, paradoxically, place susceptible horses at risk for AHS. |
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| فهرسة مساهمة: | Keywords: African horse sickness; asymptomatic viral infections; environmental vaccine identification; genome reassortment; live attenuated vaccine; reversion; vaccine progenitor availability; vaccine transmission; veterinary epidemiology; virulence; viruses |
| المشرفين على المادة: | 0 (Vaccines, Attenuated) 0 (Viral Vaccines) |
| تواريخ الأحداث: | Date Created: 20160722 Date Completed: 20180112 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5189153 |
| DOI: | 10.3201/eid2212.160718 |
| PMID: | 27442883 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1080-6059 |
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| DOI: | 10.3201/eid2212.160718 |