دورية أكاديمية
أعرض في EDS

Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing.

التفاصيل البيبلوغرافية
العنوان: Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing.
المؤلفون: Jones LR; Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Rivadavia 1917 (C1083ACA), Buenos Aires, Argentina.; Laboratorio de Virología y Genética Molecular, Facultad de Ciencias Naturales sede Trelew, Universidad Nacional de la Patagonia San Juan Bosco, 9 de Julio y Begrano S/N (9100), Trelew, Chubut, Argentina., Sede M; Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Rivadavia 1917 (C1083ACA), Buenos Aires, Argentina.; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155-Piso 11, C1121ABG, Buenos Aires, Argentina., Manrique JM; Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Rivadavia 1917 (C1083ACA), Buenos Aires, Argentina.; Laboratorio de Virología y Genética Molecular, Facultad de Ciencias Naturales sede Trelew, Universidad Nacional de la Patagonia San Juan Bosco, 9 de Julio y Begrano S/N (9100), Trelew, Chubut, Argentina., Quarleri J; Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Rivadavia 1917 (C1083ACA), Buenos Aires, Argentina. quarleri@fmed.uba.ar.; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155-Piso 11, C1121ABG, Buenos Aires, Argentina. quarleri@fmed.uba.ar.
المصدر: Archives of virology [Arch Virol] 2016 Oct; Vol. 161 (10), pp. 2885-91. Date of Electronic Publication: 2016 Jul 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wien, New York, Springer-Verlag.
مواضيع طبية MeSH: Amino Acid Substitution* , Drug Resistance, Viral* , High-Throughput Nucleotide Sequencing*, Hepatitis B virus/*drug effects , Hepatitis B virus/*genetics, Adult ; Antiviral Agents/therapeutic use ; Female ; Genotype ; Hepatitis B virus/classification ; Hepatitis B virus/isolation & purification ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/virology ; Humans ; Longitudinal Studies ; Male ; Phylogeny
مستخلص: HBV phylogenetics and resistance-associated mutations (RAMs) were surveyed by next-generation sequencing of 21 longitudinal samples from seven patients entering antiviral therapy. The virus populations were dominated by a few abundant lineages that coexisted with substantial numbers of low-frequency variants. A few low-frequency RAMs were observed before treatment, but new ones emerged, and their frequencies increased during therapy. Together, these results support the idea that chronic HBV infection is dominated by a few virus lineages and that an accompanying plethora of diverse, low-frequency variants may function as a reservoir that potentially contribute to viral genetic plasticity, potentially affecting patient outcome.
المشرفين على المادة: 0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20160723 Date Completed: 20170123 Latest Revision: 20170123
رمز التحديث: 20221213
DOI: 10.1007/s00705-016-2959-8
PMID: 27447462
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-8798
DOI:10.1007/s00705-016-2959-8